Overview
Fresno sits at the center of California’s San Joaquin Valley, and over the last decade the city has developed a growing ecosystem of regenerative medicine providers. What was once limited to academic medical centers in Los Angeles or San Francisco is now accessible to Central Valley residents without the drive. Board-certified physicians with fellowship training in anti-aging medicine, osteopathic family medicine, and internal medicine have established clinics in and around Fresno that offer platelet-rich plasma (PRP) therapy, exosome infusions, peptide protocols, and biologic joint injections. The result is a local market where patients dealing with chronic pain, orthopedic injuries, and age-related decline can consult specialists who combine regenerative tools with conventional medical oversight.
Conditions commonly addressed at Fresno-area regenerative medicine clinics span a wide spectrum. On the musculoskeletal side, patients seek treatment for osteoarthritis in knees, hips, shoulders, and hands; rotator cuff and Achilles tendon tears; spinal disc degeneration; sciatica; and sports injuries ranging from ligament sprains to patellar tendonitis. Beyond orthopedics, several local practices treat systemic conditions including fibromyalgia, peripheral neuropathy, and certain inflammatory disorders. Hormonal and metabolic concerns — low testosterone, menopause-related symptoms, and metabolic syndrome — are also part of the regenerative medicine umbrella at many Fresno clinics, as physicians recognize that cellular repair and hormonal optimization are deeply interconnected. Because these treatments work by stimulating the body’s own repair mechanisms rather than masking symptoms, they attract patients who have already exhausted conventional options like steroid injections and physical therapy without satisfactory results.
During a typical consultation at a Fresno regenerative medicine clinic, a physician will review imaging studies, prior treatment history, and current functional limitations before recommending a protocol. Most clinics require that patients have tried and documented less invasive conservative care first. Treatment itself is largely outpatient and office-based: PRP procedures involve drawing a small amount of the patient’s blood, spinning it in a centrifuge to concentrate growth factors, and injecting the resulting solution into the target tissue under ultrasound or fluoroscopic guidance. Exosome and biologic therapies involve intravenous or direct tissue infusions of cell-signaling molecules derived from donor tissue or the patient’s own blood. Downtime is minimal — most patients return to normal daily activity within 24 to 48 hours — though full clinical benefit typically unfolds over 8 to 12 weeks as tissue remodeling occurs.
Choosing the right provider in Fresno requires attention to several factors beyond proximity. Physician credentials matter: look for an MD or DO who has completed formal fellowship training in regenerative or anti-aging medicine through a recognized institution, not simply a weekend certification course. Transparency about what specific biologics are used, where they are sourced, and how they are handled is a baseline expectation. Reputable clinics will also give honest assessments of candidacy rather than promising results to every patient. A red flag is any clinic that refuses to discuss failure rates or that positions its treatments as cures for conditions with no peer-reviewed evidence base. Finally, cost and financing should be discussed openly: regenerative therapies are rarely covered by health insurance, and typical procedure costs in California range from several hundred dollars for a single PRP injection to several thousand dollars for comprehensive biologic protocols.
Top Stem Cell Therapy Clinics in Fresno, CA
1. Optimal Medical Group
Address: 7206 N. Milburn Ave, Suite 106, Fresno, CA 93722
Phone: (559) 840-0066
Website: https://omgwellnessmd.com
Physician: Dr. Juan Chavez, MD, Board-Certified Internal Medicine, Anti-Aging and Regenerative Medicine; Dr. Lucia Mireles-Chavez, MD
Services:
- Exosome therapy (IV infusion and local injection)
- Platelet-Rich Plasma (PRP) injections
- Bioidentical hormone replacement therapy
- Medical weight loss
- IV nutrient therapy and ketamine IV therapy
- Hair restoration
- GAINSWave acoustic wave therapy
- Non-surgical body contouring (Morpheus8)
Conditions Treated:
- Osteoarthritis (knee, hip, shoulder, spine)
- Rotator cuff and Achilles tendon injuries
- Degenerative disc disease and spinal stenosis
- Sciatica and carpal tunnel syndrome
- Peripheral neuropathy and fibromyalgia
- Low testosterone and menopause-related hormone decline
- Erectile dysfunction
About: Optimal Medical Group is led by Dr. Juan Chavez, MD, who earned his medical degree from UC Davis in 1997 and completed his Internal Medicine Residency at UCSF-Fresno in 2000. After more than 15 years in critical care medicine, Dr. Chavez transitioned to regenerative and longevity medicine to address the root causes of aging and chronic disease rather than managing symptoms. The practice holds consecutive Best Men’s Health awards for 2023, 2024, and 2025 from local recognition programs and has accumulated over 230 five-star patient reviews. Dr. Lucia Mireles-Chavez, MD co-leads the practice, bringing additional depth to the team’s hormone optimization and women’s health offerings.
2. The Allende Centre for Regenerative Medicine and Vitality
Address: 6234 N. First St, Fresno, CA 93710
Phone: (559) 282-8835
Website: https://www.allendecentre.com
Physician: Dr. Diego G. Allende, DO, Board-Certified Family Medicine, College of Osteopathic Medicine of the Pacific
Services:
- Stem cell injections (joint and tissue)
- Platelet-Rich Plasma (PRP) therapy
- Joint injections for pain and mobility
- Sports medicine and injury rehabilitation
- Bioidentical hormone replacement therapy
- Aesthetic treatments (dermal fillers, laser therapy, body contouring with Harmony XL PRO)
- Weight loss and nutritional counseling
- Vitamin and IV therapy
Conditions Treated:
- Osteoarthritis
- Sports injuries (ligament, tendon, and cartilage damage)
- Chronic joint pain
- Musculoskeletal injuries requiring non-surgical intervention
- Hormonal imbalances in men and women
- Weight management and metabolic concerns
About: Dr. Diego Allende launched his Fresno medical center in 2007 and has spent more than 15 years building it into one of the Central Valley’s most recognized regenerative medicine practices. He trained in osteopathic medicine and holds board certification in family medicine, and his clinical philosophy has long centered on treating the whole patient rather than individual symptoms in isolation. The Allende Centre has earned a 4.76 out of 5 star average across 279 patient reviews, with long-term patients regularly citing the practice’s personalized approach and Dr. Allende’s direct involvement in each case. His particular focus on sports-related injuries makes the clinic a strong choice for active patients and athletes who want a surgical alternative.
3. Fresno Integrative MD
Address: 1354 W. Herndon Ave, Fresno, CA 93711
Phone: (559) 298-9600
Website: https://fresnointegrativemd.com
Physician: Dr. Ignacio Guzman, MD, Board-Certified Family Medicine; Fellowship in Cellular Medicine and Peptides (SSRP); Fellowship in Anti-Aging Medicine (A4M)
Services:
- Peptide therapy
- Bioidentical hormone replacement therapy
- Joint injections (regenerative)
- IV nutrient therapy
- Men’s sexual health and dysfunction treatment
- Cosmetic services and laser therapy
- Comprehensive anti-aging and longevity protocols
Conditions Treated:
- Chronic fatigue and low energy
- Hormonal decline (low testosterone, adrenal insufficiency)
- Joint pain and connective tissue degeneration
- Sexual dysfunction
- Weight management resistance
- Skin aging and cosmetic concerns
About: Dr. Ignacio Guzman earned his medical degree from the University of Utah School of Medicine and completed his residency at the University of California-San Francisco in Fresno, where he served as co-chief resident. He subsequently pursued advanced fellowship training in both cellular medicine and peptides through Seeds Scientific Research and Performance (SSRP) and in anti-aging medicine through the Academy for Anti-Aging Medicine (A4M), making him one of the more formally credentialed regenerative medicine physicians in the Fresno area. His practice takes an integrative approach that combines regenerative interventions with optimization of diet, lifestyle, and hormonal balance, positioning it as a strong fit for patients whose symptoms overlap multiple systems rather than a single localized injury.
What to Know Before Choosing a Stem Cell Clinic in Fresno
Before scheduling a consultation, prepare a short list of direct questions for the physician or their clinical coordinator. Ask specifically which biologic agent will be used — autologous PRP drawn from your own blood, donor-derived exosomes, or another product — and request documentation on how that product is sourced, stored, and handled. Ask about the physician’s own fellowship or post-graduate training in regenerative medicine, not simply their general medical license. A well-run clinic will answer these questions without defensiveness and provide written treatment proposals rather than verbal estimates. Ask how outcomes are tracked: does the practice use validated functional scoring tools to measure improvement, and will you have a follow-up protocol that includes reassessment at 6 and 12 weeks?
There are several red flags worth knowing before you visit a clinic in the Fresno area. Avoid any practice that guarantees outcomes or uses the word “cure” in connection with chronic degenerative conditions. Be cautious of clinics that skip a thorough intake exam — review of imaging, physical examination, and medical history — and move directly to a treatment recommendation in the first appointment. Extremely low advertised prices can signal that a clinic is using lower-quality or poorly characterized biologic products. Conversely, extremely high prices without a clear explanation of what is included can signal aggressive upselling. A reputable clinic will also tell you directly when you are not a good candidate for regenerative therapy and will recommend alternative care rather than proceeding regardless.
Cost and insurance context is important to understand before committing to treatment. In California, regenerative therapies including PRP, exosome injections, and biologic joint procedures are generally not covered by commercial health insurance or Medicare because they are categorized as experimental or investigational by most payers. Out-of-pocket costs at Fresno-area clinics typically range from approximately $500 to $1,500 for a single PRP injection, and $2,000 to $6,000 or more for multi-session protocols involving exosomes or broader biologic treatments. Some clinics offer financing plans or accept health savings account (HSA) and flexible spending account (FSA) funds, so it is worth asking at the time of consultation. Getting a written breakdown of all fees — consultation, imaging guidance, the biologic agent itself, and follow-up appointments — before signing any agreement protects you from unexpected charges.
The practical next step is a consultation, not a commitment. All three clinics listed in this guide accept new patients and offer initial consultations where the physician reviews your history and determines whether you are a genuine candidate. Bring any relevant imaging (MRI, X-ray) or prior procedure notes from orthopedic surgeons or primary care physicians, as this documentation speeds up the evaluation and gives the regenerative medicine physician a clearer clinical picture. If a clinic declines to treat you because your condition is outside their scope or your candidacy is low, treat that as a sign of integrity rather than a rejection. The goal of regenerative medicine is to match the right therapy to the right patient — not to fill a treatment schedule. For most Fresno residents, starting with a consultation at one of the physician-led practices listed above is a low-risk way to learn whether a regenerative approach fits your specific situation.
Disclaimer: This directory is for informational purposes only. Inclusion does not constitute endorsement. Verify credentials and consult a licensed physician before pursuing any treatment.