Overview
Oklahoma City has grown into one of the most medically active mid-sized metros in the south-central United States, with a healthcare system anchored by institutions such as OU Health, Integris, Mercy, and a growing network of specialty outpatient practices. That infrastructure has created fertile ground for regenerative and interventional medicine to expand. Over the past decade, a distinct tier of outpatient clinics staffed by fellowship-trained and board-certified physicians has emerged in the metro area, offering procedures that sit at the intersection of pain medicine, orthopedics, and cellular biology.
Patients seek stem cell therapy and related regenerative treatments in Oklahoma City for several overlapping reasons. Many arrive after exhausting conservative care options for musculoskeletal conditions, including physical therapy, corticosteroid injections, and anti-inflammatory medication, without achieving durable relief. Others want to explore non-surgical pathways before committing to orthopedic surgery for conditions such as knee osteoarthritis, rotator cuff tears, or degenerative spine disease. A smaller but growing segment comes specifically for wellness and longevity applications, including hormone optimization, exosome therapy, and peptide protocols aimed at cellular repair and resilience rather than a single orthopedic injury.
The types of clinics offering regenerative medicine in Oklahoma City reflect the breadth of the field itself. Interventional pain management practices led by anesthesiologists use autologous biologics, meaning cells and growth factors drawn from the patient’s own blood or bone marrow, to treat spine and joint conditions. Regenerative wellness centers combine biologics with systemic therapies such as intravenous nutrition, hormone restoration, and advanced modalities like pulsed electromagnetic field therapy. Franchise-affiliated network providers give patients access to standardized protocols developed and tracked across large patient registries. Understanding which model a clinic operates under is a practical first step in matching the right care setting to a specific clinical need.
Evaluating any stem cell clinic in Oklahoma City requires attention to a few non-negotiable factors. The treating physician should hold an active Oklahoma medical license and carry board certification in a relevant specialty such as anesthesiology, pain medicine, or physical medicine and rehabilitation. Procedures should be performed using the patient’s own cells, drawn and processed on the same day, or clearly disclosed donor-source biologics with traceability documentation. Reputable clinics use image guidance, either ultrasound or fluoroscopy, for precise delivery of injectates into target tissue. Prospective patients should ask whether the practice participates in any patient outcome registry, request an itemized explanation of what biological product is being injected, and confirm that the procedure is being presented as an adjunct or alternative rather than a guaranteed cure. The clinics below have been identified based on publicly verifiable information and represent three distinct but credible approaches to regenerative medicine in the Oklahoma City area.
Top Stem Cell Therapy Clinics in Oklahoma City
1. Orthobiogen
Address: 13100 N. Western Ave., Suite 300, Oklahoma City, OK 73114
Phone: (405) 697-3436
Website: https://orthobiogen.com
About: Orthobiogen is Oklahoma’s only licensed Regenexx provider, which distinguishes it from general regenerative medicine clinics in a meaningful way. Regenexx is a physician-only network that mandates adherence to specific preparation protocols, outcome tracking through a centralized registry, and rigorous imaging-guided delivery standards that exceed what most stand-alone clinics implement. The practice focuses exclusively on spine and joint conditions, meaning patients are not directed toward unrelated wellness services but receive care concentrated on musculoskeletal disease and injury. Orthobiogen operates multiple Oklahoma locations with the Oklahoma City office serving as the flagship, and the clinic’s staff carries a combined healthcare experience exceeding 125 years. The facility is equipped with high-frequency ultrasound diagnostics, electromyography capabilities, and digital spinal fluoroscopy, which are the imaging tools required to deliver precise injectates to the correct anatomical target rather than approximating placement by surface landmarks.
Physicians:
- Dr. Keley John Booth, MD — Board-certified diplomat of the American Board of Anesthesiology; subspecialty training in interventional pain management; graduate of the University of Oklahoma College of Medicine; completed anesthesiology residency at the University of Oklahoma Health Sciences Center; internship at Integris Baptist Medical Center; over 20 years of clinical experience; founder and president of Elite Pain and Health, a statewide interventional pain management practice; former president-elect of medical staff and chair of the Department of Anesthesiology and Pain Management at a major Oklahoma City hospital for over eight years; expert in regenerative orthopedic procedures under the Regenexx protocol.
Services:
- Platelet-Rich Plasma (PRP) — Orthobiogen’s advanced platelet procedures use a more concentrated and purer preparation than standard automated-machine PRP, increasing the density of growth factors delivered to soft tissue injuries, mild arthritis, spine conditions, and nerve-adjacent pathology.
- Bone Marrow Concentrate (Regenexx-SD) — Bone marrow is harvested from the posterior iliac crest, concentrated to maximize the stem cell population, and precisely injected into the injured area under imaging guidance, targeting conditions where cartilage or structural tissue repair capacity is needed.
- Regenexx Non-Surgical Injection Protocols — Standardized, image-guided delivery of autologous biologics following Regenexx network procedures with outcomes tracked in a registry that accounts for 44 percent of the world’s published research on bone marrow concentrate use in orthopedics.
Conditions Treated:
- Knee osteoarthritis and bone-on-bone knee pain
- Rotator cuff tears and shoulder joint degeneration
- Hip arthritis and labral pathology
- Spine conditions including cervical and lumbar disc disease
- Tendonitis and ligament tears
- Carpal tunnel syndrome
- Osteoarthritis in multiple joints
Technology and Equipment: High-frequency diagnostic ultrasound; digital spinal fluoroscopy; electromyography; Regenexx-certified preparation protocols for both platelet and bone marrow concentrate procedures.
Patient Experience: Based on publicly tracked outcomes data, Regenexx knee patients report an average 37 percent improvement in joint function after one month, with continued improvement over time. The clinic accepts new patients Monday through Thursday 9:00 AM to 5:00 PM and Friday 9:00 AM to 3:00 PM.
2. Oklahoma Pain Physicians
Address: 4117 NW 122nd Street, Suite C, Oklahoma City, OK 73120
Phone: (405) 463-3380
Website: https://okpainphysicians.com
About: Oklahoma Pain Physicians is a multi-location interventional pain management practice with its primary Oklahoma City location on the northwest side of the metro, along with offices in Norman and Purcell. The practice is directed by a physician with one of the most extensive credentialing profiles in Oklahoma pain medicine, and its regenerative medicine services are integrated into a comprehensive pain management framework rather than offered as standalone boutique treatments. This positioning means that patients who come in for stem cell therapy or PRP also have access to a full diagnostic and interventional pain workup, which can improve both the precision of biologic placement and the clinical context for determining whether regenerative treatment is the right tool for a given condition. The clinic’s approach to regenerative medicine is to incorporate it alongside individualized pain management plans rather than substituting it for a thorough patient evaluation.
Physicians:
- Dr. Rafael Justiz III, MD — Quadruple board-certified physician; certifications from the American Board of Anesthesiology in anesthesia and subspecialty pain management, the American Board of Interventional Pain Physicians, Fellow of the World Institute of Pain, and certification from the American College of Sports Medicine; BS and MS in health education from Florida International University; Doctor of Medicine from the Medical College of Wisconsin; internship and residency in anesthesiology at the University of South Florida College of Medicine; interventional pain management fellowship at Texas Tech University Health Sciences Center, Department of Anesthesiology and Pain Management; president and CEO of the Oklahoma Society of Interventional Pain Physicians; regional vice-chair for the World Institute of Pain for the United States; board of directors member of the American Society of Interventional Pain Physicians.
- Dr. Alina Justiz, MD — Co-physician offering regenerative medicine and pain management services alongside Dr. Rafael Justiz.
Services:
- Stem Cell Therapy (Mesenchymal) — Injection of mesenchymal stem cells, either autologous or sourced from umbilical cord tissue of healthy full-term donors, directly into injured or damaged tissue to stimulate the body’s healing cascade and flood the target site with repair-capable cells.
- Platelet-Rich Plasma (PRP) Injections — A sample of the patient’s blood is processed to produce a serum containing five to ten times the normal platelet concentration, which is then injected into damaged tissue to deliver a concentrated payload of growth factors and proteins that drive cellular repair.
- Comprehensive Interventional Pain Management — Diagnostic workup and individualized treatment plans that may incorporate regenerative therapies alongside nerve blocks, radiofrequency ablation, spinal cord stimulation, and other interventional modalities.
Conditions Treated:
- Chronic pain and benign chronic pain syndrome
- Neck, head, and back pain
- Degenerative joint disease and osteoarthritis
- Sports injuries and soft tissue pathology
- Ligament and tendon injuries amenable to biologic augmentation
- Pain conditions where conservative care has been insufficient
Insurance and Pricing: Regenerative medicine services including stem cell therapy and PRP are typically not covered by insurance. Patients should contact the clinic directly for current pricing and payment options.
3. Ethos Wellness Center
Address: 101 E Memorial Road, Suite 140, Oklahoma City, OK 73131
Phone: (405) 237-8558
Website: https://www.ethoswellnessok.com
About: Ethos Wellness Center occupies a distinct niche within the Oklahoma City regenerative medicine landscape by positioning itself as a preventative and restorative health practice rather than a purely orthopedic or pain-focused clinic. Under the medical direction of Dr. Joseph Palmeri, MD, the clinic brings a systems biology orientation to patient care, emphasizing that most chronic conditions are insufficiently addressed by symptom suppression and that long-term wellness requires interventions targeted at root cellular and hormonal dysfunction. This philosophy translates into a service offering that combines stem cell-derived exosome therapy with hormone optimization, peptide protocols, IV nutritional therapy, ketamine infusions, and contrast therapy modalities, creating a vertically integrated wellness program that treats the patient as a whole system rather than a collection of isolated complaints. The practice offers a free initial consultation and sees patients Monday through Friday from 9:00 AM to 5:00 PM, with extended-hours availability on some schedules.
Physicians:
- Dr. Joseph Palmeri, MD — Board-certified anesthesiologist; BS in biomedical science from Oklahoma State University; Doctor of Medicine from the University of Oklahoma College of Medicine; internship in internal medicine at the University of Oklahoma School of Community Medicine (Tulsa); three-year residency in anesthesiology at NYU Grossman School of Medicine (New York University Department of Anesthesiology), where he trained across pediatric, abdominal, interventional radiology, and thoracic surgical specialty areas; testamur status in transesophageal echocardiography; member of the American Medical Association, Oklahoma State Medical Association, and American Society of Anesthesiologists; over 15 years of clinical experience.
Services:
- Stem Cell-Derived Exosome Therapy — Exosomes are extracellular vesicles derived from stem cells that carry regenerative signals, growth factors, and micro-RNA into target tissue to drive repair and reduce inflammation at the cellular level; this approach supplements the body’s own healing organelles without requiring autologous cell harvesting.
- Hormone Optimization and Testosterone Replacement Therapy — Customized hormone restoration plans for men and women experiencing low testosterone, fatigue, low libido, or cognitive impairment, delivered via pellets or injections with ongoing monitoring to maintain physiologic balance.
- Peptide Therapy — Evidence-informed peptide protocols targeting the musculoskeletal, immune, and nervous systems to support anabolic-catabolic balance, strength, recovery, memory, and cognition.
- IV Infusion Services — Intravenous delivery of vitamins, trace minerals, glutathione, and other therapeutic compounds to replenish deficiencies, combat fatigue, and accelerate tissue recovery.
- Ketamine Infusion Therapy — Image-guided ketamine protocols for treatment-resistant anxiety, depression, PTSD, and mood disorders; Dr. Palmeri brings anesthesiology-level expertise to ketamine administration, which increases safety margins compared to non-anesthesiologist-managed infusion settings.
- PEMF Therapy — Pulsed electromagnetic field therapy using PulsePEMF technology to enhance cellular repair, support circulation, and promote deep recovery.
- Contrast Therapy and Red Light Therapy — Hormetic stress modalities that challenge the autonomic and immune systems to reinvigorate the central nervous and hormonal system.
- Genomic Testing — Personalized health blueprint based on genomic data to optimize diet, exercise, and therapeutic protocols.
Conditions Treated:
- Tissue damage and chronic inflammation
- Hormonal imbalance and low testosterone
- Fatigue, low energy, and mitochondrial dysfunction
- Treatment-resistant depression, anxiety, and PTSD
- Cognitive decline and mental fog
- Nutritional deficiencies and metabolic dysfunction
- Longevity and cellular anti-aging
Patient Experience: The clinic features Oklahoma City’s first dedicated contrast therapy room and emphasizes a patient-centered experience with free confidential consultations. Dr. Palmeri holds a 5.0-out-of-5 patient rating based on published reviews.
What to Know Before Choosing a Stem Cell Clinic in Oklahoma City
Choosing a regenerative medicine provider in Oklahoma City requires asking specific questions before committing to any protocol. The single most important question is what biological product is actually being injected. Terms like “stem cell therapy” are used loosely across the industry, and the gap between autologous bone marrow concentrate, umbilical cord-derived mesenchymal stem cells, exosome preparations, and generic platelet-rich plasma is significant in terms of regulatory status, mechanism of action, and clinical evidence. A credible clinic will give a plain-language explanation of exactly what the injectate contains, where it originates, how it is processed, and what published research supports its use for the patient’s specific condition. Clinics that avoid these questions or pivot to testimonials rather than mechanism explanations warrant caution.
Imaging capability is a practical differentiator that patients often overlook. Delivering biologics to a knee joint, a herniated disc, or a torn rotator cuff requires precision that cannot be achieved by palpation-guided injection alone. Ultrasound guidance allows real-time visualization of needle placement in soft tissue structures, while fluoroscopy is required for accurate spinal injections. Any clinic offering to inject near the spine or into a deep joint without imaging confirmation is applying a blunt instrument to a task that requires surgical accuracy. Before scheduling any procedure, ask the clinic to confirm which imaging modality will be used for your specific injection and who holds credentialing to operate that equipment.
Board certification and fellowship training are not interchangeable with general licensure. Oklahoma requires all practicing physicians to hold a valid state medical license, but licensure alone does not indicate specialty competency in regenerative medicine. When evaluating a physician, confirm board certification in a relevant specialty such as anesthesiology, interventional pain management, physical medicine and rehabilitation, or orthopedic surgery. Fellowship training in interventional pain or orthobiologics provides an additional layer of procedural depth that translates directly into injection accuracy and complication awareness. The Oklahoma Medical Board maintains a public license verification portal, and national certifications can be confirmed through the American Board of Medical Specialties. These verifications take less than five minutes and are worth the effort before any procedure.
Finally, understand the realistic role that regenerative medicine plays in a comprehensive care plan. None of the procedures described in this directory carry FDA approval as standalone treatments for any specific condition, and the evidence base, while growing and in some cases compelling, is still maturing. Bone marrow concentrate procedures such as Regenexx-SD have the largest published outcomes datasets in the orthobiologics space, but individual results vary based on age, severity of degeneration, injection accuracy, and post-procedure rehabilitation compliance. Legitimate Oklahoma City clinics will be transparent about expected timelines, note that symptomatic improvement typically unfolds over weeks to months rather than days, discuss what conventional alternatives exist, and recommend follow-up imaging or functional assessment to track response. A provider who promises rapid or guaranteed outcomes without these nuances is not operating within the scientific consensus.
Disclaimer: This directory is for informational purposes only and is based on publicly available information as of the date of publication. Inclusion does not constitute endorsement of any clinic or physician. All addresses, phone numbers, physician credentials, and services should be independently verified before scheduling any appointment. Consult a licensed physician before pursuing any treatment. The author makes no representations regarding clinical outcomes.