Overview
Plano, Texas has become one of the Dallas-Fort Worth metroplex’s most active hubs for regenerative medicine and stem cell therapy. The city’s concentration of board-certified pain management physicians, orthopedic specialists, and interventional spine practitioners reflects a broader shift in how North Texas patients approach chronic pain and musculoskeletal injury. Rather than defaulting to long-term opioid management or invasive surgery as a first resort, a growing number of Plano-area providers now offer cell-based and biologic treatments that work with the body’s own repair mechanisms. This maturation of the local market means patients have access to clinics staffed by fellowship-trained physicians, many of whom have received advanced training at nationally recognized academic medical centers.
The conditions most commonly treated at Plano stem cell clinics range from degenerative joint disease and osteoarthritis of the knee, hip, and shoulder to tendon and ligament injuries, meniscus tears, rotator cuff damage, and chronic spinal pain from degenerative disc disease. Platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and amniotic or umbilical cord-derived cellular tissue products are the most widely used biologics in the area. Each carries a different mechanism of action: PRP concentrates growth factors from the patient’s own blood to reduce inflammation and stimulate repair, BMAC harvests regenerative cells from the patient’s own bone marrow, and allograft cellular tissue introduces donor-sourced growth factors and cytokines to the injury site. Physicians who specialize in these therapies typically use image guidance, such as fluoroscopy or ultrasound, to place injections with precision.
Patients considering stem cell therapy in Plano should understand the general arc of treatment. An initial consultation involves a detailed history, imaging review, and physical examination to determine whether a regenerative approach is appropriate for the specific diagnosis. The injection procedure itself is typically brief, often completed in under fifteen minutes. Recovery varies by treatment type and injury severity, but most patients return to their normal routines the same day. Clinical improvement is gradual rather than immediate: many patients begin noticing benefit within two to four weeks, with peak results commonly reported at three to six months as the treated tissue remodels and regenerates. Follow-up visits allow the physician to track progress and adjust the treatment plan if needed.
Choosing the right provider in Plano requires evaluating both credentials and clinical approach. The strongest indicator of a trustworthy clinic is a physician with an MD or DO and board certification in a relevant specialty, such as physical medicine and rehabilitation, pain management, orthopedic surgery, or anesthesiology, combined with fellowship training in interventional procedures. Transparency about which biologic product is being used, where it is sourced, and what peer-reviewed evidence supports the protocol is equally important. Patients should be cautious of clinics that make absolute cure claims, pressure rapid decisions, or refuse to discuss realistic outcomes and failure rates. The most credible practices in Plano follow evidence-based protocols, use licensed FDA-regulated products, and integrate regenerative treatments into a broader care plan that may include physical therapy, diagnostic imaging, and lifestyle modification.
Top Stem Cell Therapy Clinics in Plano, TX
1. Tarpon Interventional Pain & Spine Care
Address: 8080 Independence Pkwy, Suite 110, Plano, TX 75025
Phone: (972) 596-1059
Website: https://tarponpa.com
Physician: Dr. Meriwether Lewis Frazier Jr., MD, Physical Medicine & Rehabilitation, Board-Certified by the American Board of Physical Medicine and Rehabilitation
Services:
- Stem cell therapy using bone marrow aspirate concentrate (BMAC)
- Platelet-rich plasma (PRP) therapy
- Regenerative medicine consultations
- Interventional pain management
- Spinal cord stimulation
- Radiofrequency ablation
- SoftWave therapy
- Sports medicine
Conditions Treated:
- Chronic joint pain (knee, hip, shoulder)
- Ligament and tendon tears
- Meniscus injuries
- ACL and PCL tears
- Rotator cuff damage
- Achilles tendon pathology
- Degenerative disc disease
- Osteoarthritis
- Cartilage damage
About: Tarpon Interventional Pain & Spine Care is led by Dr. Lewis Frazier Jr., MD, who completed his residency training at Stanford University, where he served as chief resident, and holds board certification in Physical Medicine and Rehabilitation. Dr. Frazier is a Fellow of the American Association of Neuromuscular and Electrodiagnostic Medicine, has been named to D Magazine’s Best Doctors list multiple times, and is a repeated recipient of the Texas Super Doctor Award. His stem cell protocols concentrate on harvesting cells from the patient’s own bone marrow, blood, and adipose tissue to create personalized biologic injections, reducing the risk of rejection and aligning with the body’s natural healing architecture.
2. Holistiq Spine & Orthopaedic
Address: 5655 W Spring Creek Pkwy, Suite 115, Plano, TX 75024
Phone: (469) 444-7246
Website: https://goholistiq.com
Physician: Dr. Trung Ha, MD, Interventional Pain Medicine; Dr. Yasmin Fatemi, MD, Interventional Pain Medicine; Dr. Raphael Ye, DO, Interventional Pain Medicine
Services:
- Mesenchymal stem cell therapy (autologous, from adipose tissue or bone marrow)
- Platelet-rich plasma (PRP) therapy
- Interventional pain injections
- Chiropractic care
- Physical therapy
- Acoustic wave therapy
- Nutrition counseling
- Comprehensive spine and joint consultations
Conditions Treated:
- Osteoarthritis of the knee, hip, and shoulder
- Tendon and ligament injuries
- Chronic back and neck pain
- Sports injuries
- Degenerative disc disease
- Spinal injuries
- Soft tissue injuries
About: Holistiq Spine & Orthopaedic is a multi-disciplinary clinic that brings together board-eligible and board-certified interventional pain physicians under one roof, with Dr. Trung Ha, MD serving as the clinic’s founding physician and CEO. The practice takes a whole-person approach to musculoskeletal care, combining regenerative cell therapies with physical rehabilitation, chiropractic treatment, and nutritional support. Stem cell procedures at Holistiq use mesenchymal stem cells harvested from the patient’s own adipose tissue or bone marrow, which the team describes as ensuring a safe, autologous process that minimizes immune response while maximizing the concentration of healing factors delivered to the target tissue.
3. ReGen Pain Management
Address: 6020 West Parker Road, Suite 300, Plano, TX 75093
Phone: (469) 252-4777
Website: https://www.regenpainclinic.com
Physician: Dr. Jonathan Koning, MD, Pain Management, Board-Certified by the American Board of Anesthesiology
Services:
- Platelet-rich plasma (PRP) injections
- Regenerative medicine consultations
- Interventional pain management
- Spinal cord stimulation
- Indirect spinal decompression
- Intrathecal drug therapy
- Back and neck pain treatment
- Knee and joint pain treatment
- Sports medicine
- Complex regional pain syndrome management
Conditions Treated:
- Chronic back and neck pain
- Joint pain (knee, hip, shoulder)
- Neuropathy and sciatica
- Headache disorders
- Complex regional pain syndrome (CRPS)
- Post-surgical pain
- Ligament and soft tissue injuries
About: ReGen Pain Management was founded in 2016 and has grown into one of the Plano and Frisco area’s most established interventional pain and regenerative medicine practices. Dr. Jonathan Koning earned his medical degree from Loma Linda University School of Medicine, completed anesthesiology training at the University of Nebraska Medical Center, and finished a pain management fellowship at the University of Toledo. Board-certified by the American Board of Anesthesiology, Dr. Koning applies a multi-dimensional, evidence-based treatment philosophy that integrates regenerative biologics such as PRP with physical therapy, interventional procedures, and individualized pain management plans. The practice maintains a 4.7-star patient rating across more than 100 verified reviews.
What to Know Before Choosing a Stem Cell Clinic in Plano
Before committing to any regenerative medicine provider in Plano, there are several questions worth asking directly during your consultation. First, ask the physician which specific biologic product will be used, whether it is autologous (derived from your own body) or allogeneic (from a donor), and how it is regulated. Reputable clinics use products processed in FDA-registered facilities and can provide documentation of product sourcing. Second, ask what imaging guidance will be used during the injection. Ultrasound or fluoroscopic guidance significantly improves the accuracy of cell delivery to the target tissue, which affects outcomes. Third, ask for a realistic range of outcomes for your specific diagnosis, including the percentage of patients who do not respond to treatment. A physician who refuses to discuss failure rates or who guarantees results is presenting an incomplete picture.
Several red flags should prompt you to seek a second opinion before proceeding. Be wary of clinics that market stem cell therapy as a universal cure for conditions spanning neurodegenerative disease, diabetes, cancer, and musculoskeletal pain all at once. These claims often exceed the current scientific evidence for any single biologic product. Similarly, aggressive upselling during a free seminar, pressure to purchase a multi-treatment package on the same day as your first visit, or an inability to name the specific product and lot number being injected are warning signs. The FDA has taken regulatory action against clinics that market unapproved stem cell products, and patients in Texas have recourse through the Texas Medical Board if a licensed physician engages in misleading or dangerous practices.
On the question of cost and insurance: most insurance carriers, including Medicare, do not cover stem cell or PRP therapy for musculoskeletal conditions, classifying them as investigational or experimental. Out-of-pocket costs in the Plano market typically range from roughly $1,000 to $3,500 per injection depending on the biologic used, the complexity of image guidance required, and the number of treatment sites. BMAC procedures, which involve harvesting bone marrow from the patient’s pelvis before processing and injecting, carry higher costs than PRP, which requires only a blood draw. Financing options are commonly available through third-party medical credit companies. It is worth asking each clinic for a written, itemized cost estimate before scheduling a procedure so you can compare total costs across providers accurately.
Once you have identified a clinic that meets your credentialing and transparency standards, the practical next step is to schedule a consultation and bring all relevant imaging, including X-rays, MRI studies, and any prior procedure notes. Arriving prepared allows the physician to give you a clinically grounded assessment of whether regenerative therapy is the right approach for your diagnosis, what specific protocol they recommend, and what the realistic timeline for improvement looks like. Plano’s concentration of fellowship-trained physicians in physical medicine, pain management, and orthopedics means patients are well-positioned to find a provider whose training and practice style align with their needs without traveling far into the broader Dallas-Fort Worth metro.
Medical Disclaimer: This directory is provided for informational purposes only and does not constitute medical advice. Stem cell and regenerative medicine therapies vary in evidence base, regulatory status, and suitability by diagnosis. Consult a licensed physician to determine whether any treatment is appropriate for your individual condition.