Overview
San Antonio is one of the largest metropolitan healthcare markets in Texas, home to a dense concentration of academic medical centers, military health systems, and specialty private practices. The city’s medical infrastructure includes UT Health San Antonio, CHRISTUS Santa Rosa Health System, Baptist Health System, and a network of independent physician-led clinics that have expanded their offerings to include regenerative medicine over the past two decades. This diversity means patients in San Antonio have access to a broader-than-average range of regenerative medicine providers, from academic-affiliated pain specialists to private anti-aging and orthopedic clinics.
Patients seek stem cell therapy and related regenerative treatments in San Antonio for many of the same reasons found nationwide: frustration with the side effect profiles of long-term medication use, a desire to avoid or delay elective surgery for joint or spine conditions, and interest in the biology of tissue repair. Chronic joint pain, degenerative disc disease, tendon injuries, and osteoarthritis are among the most common presentations that bring patients to regenerative medicine practices in this market. San Antonio’s large active-duty military and veteran population, combined with a significant percentage of adults over 50, drives consistent demand for non-surgical orthopedic interventions.
The clinics offering stem cell therapy in San Antonio fall into roughly three categories. The first is the dedicated regenerative medicine practice, where autologous cell therapies, platelet-rich plasma (PRP), and biologic injections form the core of the clinical model. The second is the integrative or anti-aging medicine clinic, which layers regenerative therapies alongside hormone optimization, aesthetic medicine, and wellness programming. The third is the interventional pain management practice, where stem cell therapy and PRP sit alongside more conventional procedures such as epidural steroid injections, nerve blocks, and spinal cord stimulation. Understanding which category a clinic belongs to can help patients match their expectations to the scope of care they will actually receive.
Evaluating a stem cell therapy clinic in San Antonio requires attention to a few concrete factors. Physician credentials matter: the treating provider should be a licensed MD or DO with verifiable board certification in a specialty relevant to the condition being treated. The source and preparation of biologic material should be clearly explained — whether cells are autologous (drawn from the patient’s own bone marrow or adipose tissue) or allogeneic (from a consenting donor such as umbilical cord tissue). Patients should ask whether the procedure is performed under image guidance, as ultrasound or fluoroscopic guidance significantly improves injection accuracy. Finally, patients should understand that while evidence for many stem cell applications continues to grow, most orthopedic and pain-related applications remain investigational and are typically not covered by health insurance.
Top Stem Cell Therapy Clinics in San Antonio
1. The Wellness & Aesthetics Medical Center
Address: 540 Oak Centre Drive, Suite 114, San Antonio, TX 78258
Phone: (210) 985-1700
Website: https://www.twaamc.com
About: The Wellness & Aesthetics Medical Center was established in 2010 and is located in the Stone Oak corridor of north San Antonio, one of the city’s most concentrated areas for specialty medical practices. The clinic operates under a longevity and preventive medicine philosophy, integrating regenerative therapies, hormone optimization, aesthetic medicine, and functional wellness into a single practice model. Dr. Vernon Williams has built the center around what he describes as science-driven solutions for energy, vitality, and age-related decline, positioning the practice as distinct from a conventional medical spa by anchoring it in physician-directed protocols. The clinic maintains multiple specialty-focused web presences, including a dedicated orthopedic stem cell site and a sexual health institute, reflecting the breadth of its clinical scope. The facility is open Monday through Thursday 9:00 AM to 5:00 PM and Friday 9:00 AM to 12:00 PM.
Physicians:
- Dr. Vernon F. Williams, MD — Regenerative and anti-aging medicine. Dr. Williams earned his BA in Biology from Harvard University and his MD from Albert Einstein College of Medicine in 1983. He completed two years of General Surgery residency at Allegheny General Hospital before serving three years as a Flight Surgeon in the US Air Force. He subsequently completed Physician Training and Certification in Age Management Medicine through a joint program of the Cenegenics Education and Research Foundation and the Foundation for Care Management. He holds the designation of Diplomat and Fellow of the American Academy of Anti-Aging, Regenerative and Functional Medicine (A4M), with Fellowships in Stem Cells, Sports Medicine, Integrative Cancer Therapies, Peptide Therapy, and Sexual Health. He is also a Fellow of the American Society for Laser Medicine and Surgery (ASLMS) and a member of the Anti-Aging Group Advisory Board.
Services:
- Live Stem Cell Therapy (Orthopedic): Autologous stem cell injections targeting damaged tendons, joints, and soft tissue. Protocols are designed to stimulate cellular regeneration and reduce pain without surgery, with applications for ACL injuries, meniscus tears, rotator cuff conditions, and chronic joint degeneration.
- Hormone Optimization and Peptide Therapy: Bioidentical hormone replacement and peptide protocols offered under the Peptide Institute of Texas brand, aimed at optimizing hormonal balance and promoting longevity.
- Aesthetic Laser Treatments: Includes MOXI non-ablative laser (Sciton) for skin tone and texture correction, BBL HERO broadband light therapy for permanent skin rejuvenation, and AquaFirmeXS for skin hydration and tightening.
- Body Contouring: EMSCULPT NEO for simultaneous muscle building and fat reduction across multiple body areas.
- Sexual Health Therapies: GAINSWave low-intensity shockwave therapy for erectile dysfunction, P-Shot (Priapus Shot), O-Shot, intra-cavernous pharmacotherapy, vaginal rejuvenation, and PRP-based nipple rejuvenation.
- Detoxification and Chelation Therapy: Whole-body detoxification protocols.
- Prevention and Wellness Program: A structured five-step plan targeting energy, hormone balance, nutrition, and quality of life improvement.
- Longevity Medicine Program: Comprehensive anti-aging program incorporating advanced regenerative and preventive therapies.
Conditions Treated:
- ACL tears and ligament injuries
- Knee tendinitis and osteoarthritis
- Meniscus tears
- Rotator cuff injuries and shoulder pain
- Back pain and spinal degeneration
- Hip pain
- Runner’s knee (patellofemoral syndrome)
- Chronic musculoskeletal pain
- Erectile dysfunction
- Low testosterone and hormone deficiency
- Age-related skin changes (hyperpigmentation, uneven tone, wrinkles)
- Chronic fatigue and energy deficiency related to hormonal decline
Patient Experience:
Patients typically begin with a consultation to evaluate their condition, review relevant imaging or labs, and determine candidacy for regenerative procedures. The clinic accepts new patients and can be reached by phone during business hours to schedule an initial visit.
2. Shaun Jackson, M.D. — Consultants in Pain Medicine
Address: 423 Treeline Park, Suite 325, San Antonio, TX 78209
Phone: (210) 546-1460
Website: https://www.drshaunjackson.com
About: Dr. Shaun Jackson has operated his pain medicine practice in San Antonio since 2008, when he joined Consultants in Pain Medicine following fellowship training at one of the country’s premier cancer centers. His practice is rooted in a physiatric approach to pain — one that emphasizes function, rehabilitation, and the restoration of quality of life alongside procedural intervention. Over the years, Dr. Jackson expanded his model to include regenerative medicine as the evidence base for biologic therapies in musculoskeletal pain grew. In 2020, he and his wife Jennifer opened Med Sync Health and Wellness at the same Alamo Heights location, extending the practice’s scope to include aesthetics, IV therapies, nutraceutical medicine, infrared therapies, and weight management. The practice operates with affiliations to Northeast Baptist Hospital, CHRISTUS Santa Rosa Health System, and Foundation Surgical Hospital of San Antonio, providing continuity of care for patients who require more intensive intervention.
Physicians:
- Dr. Shaun C. Jackson, MD — Physical Medicine and Rehabilitation, Pain Medicine. Dr. Jackson completed his undergraduate training Magna Cum Laude in Biophysics before earning his MD at Louisiana State University Health Science Center in Shreveport. He completed his Physical Medicine and Rehabilitation residency at the University of Texas Health Science Center in San Antonio, then pursued a Fellowship in Pain Medicine at MD Anderson Cancer Center in Houston — one of the most competitive pain fellowship programs in the country. He is double board certified by the American Board of Physical Medicine and Rehabilitation and in Pain Medicine. He is a member of the American Academy of Pain Medicine, the American Academy of Physical Medicine and Rehabilitation, the Bexar County Medical Society, the Texas Pain Society, and the Texas Medical Association. He has been in practice for more than 20 years.
Services:
- Cellular Biologics — PRP and Medicinal Signaling Cells: Platelet-rich plasma and mesenchymal signaling cell injections for musculoskeletal injuries, using the patient’s own growth factors to accelerate tissue repair in tendons, ligaments, joints, and muscles.
- Bone Marrow Aspirate Concentrate (BMAC): Autologous bone marrow-derived cells injected directly into injury sites to stimulate the body’s natural healing response and promote efficient tissue restoration.
- Exosome Therapy: Micro-vesicle-based cell communication therapy used for chronic joint pain, soft tissue injuries, repetitive motion injuries, inflammation reduction, and aesthetic skin applications.
- Amniotic Biologics: Amniotic fluid-derived treatments rich in growth factors, collagen, and cytokines, applied to orthopedic injuries and disorders.
- DRG (Dorsal Root Ganglion) Stimulation: Advanced neuromodulation for complex regional pain syndrome (CRPS) involving the abdomen, groin, hip, knee, and foot.
- MILD (Minimally Invasive Lumbar Decompression): Office-based procedure for lumbar spinal stenosis, restoring spinal canal space without general anesthesia or hospitalization.
- Sacroiliac Joint Stabilization: Minimally invasive fixation of the sacroiliac joint for patients with confirmed SI joint dysfunction.
- Vertebral Augmentation: Kyphoplasty or vertebroplasty for spinal compression fractures.
- Epidural Steroid Injections: Targeted anti-inflammatory injections for nerve irritation and radicular pain.
- Facet Medial Branch Block and Radiofrequency Ablation: Diagnostic and therapeutic nerve targeting for facet joint pain.
- Trigger Point Injections: For tight muscle areas contributing to localized or referred pain.
- Cancer Pain Management: Specialized pain management for patients undergoing cancer treatment.
- Electrodiagnostic Studies: EMG and nerve conduction studies for diagnosing nerve and muscle disorders.
- Aesthetics, IV Therapy, and Weight Management (Med Sync): Full integrative wellness services including infrared therapy, nutraceutical medicine, and medically supervised weight loss.
Conditions Treated:
- Chronic joint pain (knee, hip, shoulder, elbow)
- Spinal cord injury
- Herniated and degenerative discs
- Lumbar spinal stenosis
- Sacroiliac joint dysfunction
- Complex regional pain syndrome (CRPS)
- Fibromyalgia
- Neuropathy and nerve dysfunction
- Athletic and sports injuries
- Pulled and torn muscles and ligaments
- Arthritis
- Spinal compression fractures
- Chronic fatigue syndrome
- Migraines and chronic headaches
- Multiple sclerosis-related pain
- Cancer pain
- Personal injury and auto accident injuries
Patient Experience:
The practice operates in Alamo Heights with additional locations in New Braunfels (861 Landa St., New Braunfels, TX 78130) and a second San Antonio location at 2424 Babcock Road, Suite 202. Dr. Jackson accepts telehealth appointments and is accepting new patients. The practice accepts a broad range of insurance plans including Aetna, Blue Cross Blue Shield of Texas, Cigna, UnitedHealthCare, Humana, Ambetter, and others. Patients typically begin with a clinical evaluation that includes review of prior imaging and a functional assessment before a treatment plan is developed.
Insurance & Pricing:
Accepts Aetna, Blue Cross Blue Shield of Texas, Cigna, UnitedHealthCare, Humana, Ambetter, Curative, First Health, and additional plans. Regenerative medicine procedures are typically not covered by insurance and are self-pay; the office can provide pricing details during consultation.
3. South Texas Pain Institute — Shyam Purswani, MD
Address: 2425 Babcock Road, Suite 108, San Antonio, TX 78229
Phone: (210) 899-7246
Website: https://www.southtexaspaininstitute.com
About: South Texas Pain Institute has been operating in San Antonio since 1997, when Dr. Shyam Purswani opened the practice with a singular focus on pain management. For nearly three decades, the practice has served patients with chronic pain conditions ranging from back and neck injuries to post-surgical pain and sciatica. Over that time, Dr. Purswani expanded the clinic’s offerings to incorporate modern regenerative techniques, including autologous stem cell therapy, alongside its core interventional procedures. The practice maintains a multimodal treatment philosophy: no single approach is applied universally, and each patient receives a customized plan that may combine injections, regenerative biologics, physical therapy guidance, and patient education in self-management. Dr. Purswani also maintains an active educational role, giving lectures locally, regionally, and nationally on pain topics to healthcare providers, nurses, and primary care physicians. A second location serves patients at 2455 North East Loop 410, Suite 101, San Antonio, TX 78217.
Physicians:
- Dr. Shyam Purswani, MD — Interventional Pain Medicine, Anesthesiology. Dr. Purswani completed his medical education at the American University of the Caribbean, followed by clinical training at Providence Hospital in Southfield, Michigan, and a year of research at Cornell University in New York. He completed five years of residency training, beginning in New Jersey and finishing at Baylor University in Houston. He holds dual board certification in Anesthesiology and in the subspecialty of Pain Medicine. His Pain Medicine certification was recertified in January 2019, valid through 2028. He is a Fellow of Interventional Pain Practice and is affiliated with Baptist Medical Center and Methodist Hospital in San Antonio. Staff at the practice include Spanish-fluent team members, and Dr. Purswani communicates at an intermediate level in Spanish.
Services:
- Stem Cell Therapy: Autologous adult stem cell injections targeting the source of chronic pain, designed to accelerate healing and promote tissue restoration. Dr. Purswani emphasizes the use of the patient’s own cells to minimize rejection risk.
- Multiwave Locked System (MLS) Laser Therapy: Class IV laser treatment used to reduce inflammation and promote tissue repair as part of a multimodal pain management approach.
- Epidural Steroid Injections: For lumbar and cervical radicular pain stemming from disc herniation, spinal stenosis, or degenerative disc disease.
- Selective Nerve Root Blocks: Targeted injections to reduce inflammation and interrupt pain signals transmitted by specific spinal nerve roots.
- Piriformis Injections: Specialized injections for piriformis syndrome and piriformis-mediated sciatic nerve compression.
- Vertebroplasty and Kyphoplasty: Minimally invasive office-based procedures for vertebral compression fractures; designed to stabilize fractured vertebrae and reduce pain with minimal recovery time.
- Personal Injury and Auto Accident Care: Coordination of pain management care for patients involved in motor vehicle accidents, including support for patients navigating legal processes with attorneys and insurers.
Conditions Treated:
- Chronic back pain and lumbar spine conditions
- Neck pain and cervical spine disorders
- Sciatica and lumbar radiculopathy
- Disc herniation and degenerative disc disease
- Spinal stenosis
- Piriformis syndrome
- Vertebral compression fractures
- Post-surgical pain
- Personal injury and auto accident-related pain
- Chronic musculoskeletal pain
Patient Experience:
Dr. Purswani is accepting new patients and telehealth appointments. The practice accepts most major insurance plans, including PIP (Personal Injury Protection), LOP (Letter of Protection), and third-party claims — a meaningful distinction for patients recovering from auto accidents or workplace injuries. Consultations begin with a thorough review of the patient’s history and prior imaging before any interventional procedure is recommended. Patients are encouraged to play an active role in managing their own pain through self-management guidance alongside clinical treatment.
Insurance & Pricing:
Accepts most major insurance plans. Also accepts PIP, LOP, and third-party claims for personal injury cases. Stem cell therapy is typically not covered by insurance; pricing is available upon consultation.
What to Know Before Choosing a Stem Cell Clinic in San Antonio
Before committing to any stem cell therapy clinic in San Antonio, patients benefit from asking a specific set of questions during the initial consultation. The most important is credential verification: confirm that the treating physician is an MD or DO with active Texas licensure, and verify board certification through the American Board of Medical Specialties (certificationmatters.org) or the American Osteopathic Association. Board certification in a specialty relevant to your condition — orthopedic surgery, physical medicine and rehabilitation, pain medicine, or anesthesiology — is a meaningful signal of clinical rigor. Fellowship training adds another layer: a physician who completed a fellowship in pain medicine, sports medicine, or regenerative medicine has undergone supervised training beyond residency in that specific area.
The source and handling of biologic material is a question that separates well-run clinics from poorly-run ones. Ask whether your cells are autologous (from your own body) or allogeneic (from a donor). If allogeneic cells are being used, ask how the donor tissue is screened and processed, and whether the product has been registered with the FDA under the relevant regulatory framework. Ask whether your procedure will be performed under image guidance — ultrasound or fluoroscopy — because guidance dramatically improves the accuracy of injections into joints, tendons, and spinal structures, and its absence in a technically demanding procedure is a meaningful red flag. Clinics that perform image-guided procedures should have the equipment on-site and the staff trained to use it.
Pricing transparency is another area to probe directly. Most stem cell and PRP applications for musculoskeletal and pain conditions are not covered by health insurance in the United States, which means patients pay out of pocket. Legitimate clinics should be able to provide a clear cost estimate before any procedure is scheduled. Be cautious of clinics that bundle many procedures together into high-cost packages without clinical justification tailored to your specific condition, or that claim their treatments are FDA-approved for off-label applications. There is currently no FDA-approved stem cell product for orthopedic or pain indications — the FDA has approved hematopoietic progenitor cells from cord blood for specific blood disorders only. Any clinic claiming otherwise is misrepresenting the current regulatory landscape.
Finally, evaluate whether the clinic has a follow-up and outcomes-tracking process. A rigorous regenerative medicine practice will schedule follow-up appointments to assess your response to treatment, adjust the protocol if necessary, and document outcomes. Clinics that focus purely on procedure volume without a structured follow-up cadence make it difficult for patients to know whether treatment is working and what the next step should be. San Antonio has enough qualified providers in this space that patients do not need to settle for a clinic that cannot answer these questions clearly and directly.
Disclaimer: This directory is for informational purposes only. Inclusion does not constitute endorsement. Verify credentials and consult a licensed physician before pursuing any treatment.