Overview
Irvine has quietly become one of Southern California’s most active hubs for regenerative medicine. The city sits in the middle of Orange County’s dense network of research hospitals, biotech companies, and specialty medical groups, and that proximity to institutions like UC Irvine Health has shaped a local clinical culture that takes evidence-based innovation seriously. Patients in Irvine have access to board-certified physicians who practice regenerative therapies as a deliberate clinical specialty, not a side offering, and the concentration of multiple clinics within the city limits means that genuine comparison shopping is possible. Whether a patient is exploring stem cell therapy after exhausting conservative orthopedic options or investigating anti-aging and hormonal approaches for the first time, the Irvine market offers real choices backed by credentialed practitioners.
The range of conditions addressed by regenerative medicine clinics in Irvine reflects both the breadth of the field and the practical demands of an active, health-conscious population. Orthopedic injuries dominate: degenerative joint disease of the knee, hip, shoulder, and spine represent the largest share of patients who seek stem cell or platelet-rich plasma (PRP) therapy in this region. Beyond orthopedics, clinics here treat chronic pain conditions including sciatica, herniated discs, spinal stenosis, and neuropathy using regenerative injections as a bridge away from surgery or long-term opioid management. Anti-aging and hormonal optimization practices have also expanded into stem cell work, applying mesenchymal stem cell therapy derived from a patient’s own adipose (fat) tissue to autoimmune conditions, degenerative diseases, and tissue repair following injury. The common thread across all these applications is the principle of stimulating the body’s own repair mechanisms rather than replacing or removing damaged tissue.
The treatment experience at a reputable Irvine stem cell clinic typically begins with a thorough consultation and medical evaluation before any procedure is scheduled. This initial step matters: not every condition responds consistently to stem cell therapy, and a physician conducting a genuine evaluation will rule out patients who are poor candidates rather than proceed regardless. For orthopedic applications, imaging such as MRI or X-ray is usually reviewed to confirm the diagnosis and identify the precise injection site. Autologous procedures — those using a patient’s own cells — involve a same-day harvest, typically from adipose tissue or bone marrow, followed by processing and reinjection. PRP procedures are less involved but follow a similar same-day model. Recovery expectations vary by condition, and responsible clinics set realistic timelines rather than promising immediate results.
Selecting a provider in Irvine requires scrutiny beyond marketing language. The most important filter is physician credential verification: the practitioner performing or directly supervising the procedure should hold an MD or DO, be board certified in a relevant specialty (orthopedic surgery, pain management, sports medicine, or a related field), and have fellowship training that includes interventional or regenerative techniques. The clinic should offer a formal consultation before any financial commitment, provide clear documentation of what the procedure involves, and explain honestly what the current evidence supports and where uncertainty remains. Clinics that refuse to discuss FDA regulatory context, pressure patients toward large bundled packages on the first visit, or cannot clearly identify the supervising physician are worth avoiding regardless of price or convenience.
Top Stem Cell Therapy Clinics in Irvine, CA
1. OC Wellness Rejuvenation and Stem Cell Center
Address: 2171 Campus Drive, Suite 140, Irvine, CA 92612
Phone: (949) 222-0232
Website: https://www.ocwellnessstemcell.com
Physician: Dr. Michael Grossman, MD, Anti-Aging and Regenerative Medicine
Services:
- Adult mesenchymal stem cell therapy (autologous, adipose-derived)
- Platelet-rich plasma (PRP) therapy
- Bioidentical hormone replacement therapy
- Laser skin rejuvenation
- Exosome therapy
- Nutritional and herbal therapy
Conditions Treated:
- Degenerative joint disease (knee, hip, shoulder)
- Autoimmune conditions
- Tendon and ligament injuries
- Hormone imbalances (menopause, andropause, adrenal fatigue)
- Chronic inflammation and tissue degeneration
About: Dr. Michael Grossman, MD has practiced in Orange County since 1978, graduating from New York University School of Medicine, and transitioned to exclusive focus on rejuvenative and anti-aging medicine in 2009. He is a Diplomate of the American Board of Family Practice and a Cell Surgical Network partner physician. The clinic uses the patient’s own adipose-derived mesenchymal stem cells harvested, processed, and reinjected in a single same-day procedure. Dr. Grossman conducts a full medical evaluation before recommending stem cell therapy and explicitly screens out patients who are unlikely to benefit, making the intake process more rigorous than a typical wellness clinic model.
2. Pain Care Providers
Address: 113 Waterworks Way, Suite 345, Irvine, CA 92618
Phone: (949) 872-2400
Website: https://www.paincareproviders.com
Physicians: Dr. Amir Rafizad, MD, Pain Medicine and Anesthesiology; Dr. Reza Mahrou, MD, Pain Medicine and Anesthesiology
Services:
- Stem cell injections for pain management
- Platelet-rich plasma (PRP) injections
- Radiofrequency ablation
- Epidural steroid injections
- Spinal cord stimulator placement
- Nerve blocks and sympathetic blocks
- Trigger point injections
- IV therapy
Conditions Treated:
- Chronic back and neck pain
- Herniated discs
- Spinal stenosis
- Sciatica
- Degenerative joint disease
- Neuropathy
- Joint pain
About: Pain Care Providers is a dual-physician practice founded by Dr. Amir Rafizad and Dr. Reza Mahrou, both of whom are board certified in pain medicine and anesthesiology and completed fellowship training at UCLA Medical Center. Dr. Rafizad also serves as attending staff at the West Los Angeles Veterans Medical Center, and Dr. Mahrou holds an assistant clinical professorship at UCLA Health Services. The practice integrates regenerative medicine — including stem cell and PRP injections — into a comprehensive pain management framework that emphasizes conservative and minimally invasive approaches. Most major insurance plans are accepted, making this one of the more accessible entry points for regenerative care in Irvine.
3. CellCore Regenerative Medicine Institute
Address: 15785 Laguna Canyon Road, Suite 125, Irvine, CA 92618
Phone: (949) 383-4182
Website: https://cellcorestemcell.com
Physician: Dr. Todd William Peters, MD, Orthopedic Surgery and Regenerative Medicine
Services:
- Non-surgical stem cell therapy for joint and spine conditions
- Platelet-rich plasma (PRP) therapy
- Minimally invasive orthopedic procedures
- Regenerative biologics for musculoskeletal injuries
- Consultation and clinical research advisory services
Conditions Treated:
- Knee pain and degenerative knee disease
- Ankle and foot pain
- Elbow pain and tendinopathy
- Hip and shoulder degeneration
- Neck and back pain
- Spine-related conditions requiring non-surgical options
About: CellCore Regenerative Medicine Institute was founded to advance access to adult stem cell therapies in Orange County, combining orthopedic surgical expertise with regenerative biologics science. Dr. Todd William Peters, MD is a board-certified and fellowship-trained orthopedic spine surgeon recognized as a leader in minimally invasive orthopedic surgery. He holds memberships in the American Academy of Orthopaedic Surgeons (AAOS), the North American Spine Society (NASS), the American Board of Orthopaedic Surgery (ABOS), and the Society of Minimally Invasive Spine Surgery (SMISS). Dr. Peters designs individualized treatment plans using non-operative regenerative approaches as a primary strategy, with surgical options available when conservative care is insufficient.
What to Know Before Choosing a Stem Cell Clinic in Irvine
Before scheduling a consultation, a patient benefits from arriving with specific questions rather than relying entirely on the clinic’s presentation. The most important question is who performs the procedure and what their specific credentials are. A clinic marketing stem cell therapy should be able to state, without hesitation, the full name, board certification, and specialty of the physician who will administer the injection. Ask whether the physician will be present throughout or whether the procedure will be delegated to a non-physician provider. Ask which type of stem cell product is used — autologous (from your own body) versus allogeneic (from a donor) — and why that choice is appropriate for your specific condition. Ask what the published evidence says about outcomes for your diagnosis, and what realistic expectations look like at 3, 6, and 12 months. A physician who answers these questions with measured honesty is more trustworthy than one who responds primarily with testimonials and outcome statistics drawn from unreviewed internal records.
Red flags worth recognizing include any clinic that requires a large financial commitment before a full medical evaluation is completed, any facility that cannot clearly identify the supervising physician’s credentials, or any practice that claims stem cell therapy is FDA-approved for your condition when it is not. The FDA has approved very few stem cell products for specific indications, and most regenerative treatments offered at outpatient clinics in California operate under physician practice oversight rather than FDA product approval. This does not make them unsafe or unethical, but it does mean that informed consent and physician transparency matter more, not less. Be skeptical of guarantees, of claims that a single treatment will resolve a chronic degenerative condition, and of any clinic that declines to discuss the regulatory context of what they are offering.
Pricing and insurance present a consistent challenge for patients seeking regenerative therapy in Irvine. Most insurance carriers do not cover stem cell injections for orthopedic or anti-aging applications, treating them as experimental or elective. Pain Care Providers is notable for accepting major medical insurance plans for their pain management services, which may provide some coverage for related diagnostic and interventional work even where regenerative injections themselves are not reimbursed. Out-of-pocket costs for a single stem cell injection session in Orange County typically range from several hundred to several thousand dollars depending on the complexity, the source of the cells, and the number of sites treated. Patients should request a clear written fee schedule before any commitment and confirm whether the quoted price includes follow-up consultations and any repeat injections within a defined period.
The practical next step for most patients is a paid or complimentary initial consultation at one or two clinics before making a decision. Bring imaging if you have it, a written summary of prior treatments and outcomes, and a list of the specific questions outlined above. Compare not just the price and the treatment plan but the physician’s communication style, the clinic’s willingness to answer uncomfortable questions, and the quality of the intake process. A facility that handles the consultation phase with transparency and rigor is likely to handle the procedure and follow-up with the same standard. Stem cell therapy in Irvine is genuinely available from credentialed physicians — the task is identifying the practitioner whose approach to your specific condition is grounded in evidence, honest about uncertainty, and structured around your clinical goals rather than a sales outcome.
Disclaimer: This directory is for informational purposes only and does not constitute medical advice or endorsement of any clinic. All information was sourced from publicly accessible websites and directories as of February 2026 and is subject to change. Verify physician credentials through the California Medical Board at breeze.ca.gov and by contacting each clinic directly before scheduling any procedure.