Overview
Louisville, Kentucky occupies a distinctive position in the regional healthcare landscape. Home to the University of Louisville Health system, Norton Healthcare, Baptist Health, and a growing network of specialty practices, the city has long supported advanced medical care across multiple disciplines. In recent years, this infrastructure has extended into regenerative and integrative medicine, with a cluster of physician-led clinics offering therapies that go beyond conventional pain management. Patients across Jefferson County and the surrounding Kentucky counties now have access to board-certified specialists who provide regenerative treatments without requiring travel to Nashville, Cincinnati, or Indianapolis.
Patients typically seek stem cell and regenerative medicine services when conventional treatments have reached their limits. Orthopedic injuries involving cartilage, ligaments, tendons, and joints often respond poorly to long-term anti-inflammatory medication or require surgical intervention that carries significant recovery time. Regenerative approaches, including platelet-rich plasma (PRP) injections, bone marrow aspirate, and tissue allograft therapies, aim to harness the body’s own healing mechanisms to repair and restore damaged tissue. Physicians working in this space also treat chronic pain conditions, degenerative joint disease, and, in some cases, systemic conditions that have not responded to standard care. The field occupies a space where evidence is actively developing and patient outcomes vary, which makes physician credentials and institutional transparency important evaluation factors.
Louisville-area patients will encounter several distinct clinic types when exploring regenerative medicine. Academic medical centers such as UofL Health’s Brown Cancer Center offer stem cell transplant programs for hematologic malignancies, which are medically distinct from the orthopedic and musculoskeletal regenerative therapies offered at outpatient specialty clinics. The outpatient clinics covered in this guide focus on the latter category: regenerative orthobiologics, PRP, and related minimally invasive procedures administered by licensed physicians in an office-based setting. Some clinics are independent practices founded by board-certified specialists; others operate within broader integrative or functional medicine frameworks.
Evaluating a stem cell or regenerative medicine clinic requires more than reviewing a website. Patients should verify that the treating physician holds an active license in Kentucky or Indiana (for clinics across the river in the Louisville metro area) through the relevant state medical board, confirm board certification status through the American Board of Medical Specialties (ABMS) or equivalent certifying body, and ask directly about the origin and regulatory status of any biological products used in treatment. Informed patients ask whether the clinic uses fluoroscopic or ultrasound guidance for injections, since image-guided placement improves accuracy and reduces procedural risk. They also ask about realistic outcome expectations, documented patient outcomes at that specific practice, and what the plan is if initial treatment does not produce the expected result. Any clinic that guarantees a cure or makes claims inconsistent with current FDA guidance on cellular therapies deserves skepticism.
Top Stem Cell Therapy Clinics in Louisville
1. Restorative Pain Institute
Address: 4201 Springhurst Blvd, Suite 102, Louisville, KY 40241
Phone: (502) 515-6090
Website: https://www.restorativepain.org
About: Restorative Pain Institute (RPI) was founded in 2023 by Dr. Timothy J. Beacham, MD, FASA, and operates as an independent, physician-owned interventional pain practice serving the Louisville metropolitan area, with additional locations in Shelbyville and Elizabethtown, Kentucky. The practice is structured around a full-spectrum model that bridges traditional interventional pain management with regenerative medicine and functional wellness services. Dr. Beacham built RPI after more than a decade of experience leading pain management programs at multiple Kentucky institutions, including Capitol Pain Institute and Vitality Pain Center. The clinic places a stated emphasis on individualized treatment plans developed through shared decision-making between the physician and patient, recognizing that chronic pain and musculoskeletal conditions respond differently across individuals. Patients at RPI have access to regenerative therapies including stem cell therapy and platelet-rich plasma (PRP) injections, offered as part of a broader treatment approach that may also include interventional injection therapy, neuromodulation, medication management, and weight and hormone optimization. RPI received the Louisville Business First Health Care Hero award in 2024, and Dr. Beacham is recognized as one of only a small number of African American physicians specializing in interventional pain medicine in Kentucky.
Physicians:
- Timothy J. Beacham, MD, FASA — Double board certified in Anesthesiology and Interventional Pain Management. Dr. Beacham earned his BS in Chemistry from Tougaloo College (1996) and his MD from the University of Mississippi Medical Center (UMMC) School of Medicine (2005). He completed his anesthesiology residency at UMMC in 2009, followed by a fellowship in interdisciplinary pain medicine at UMMC in 2010. He previously served as an Assistant Professor of Anesthesiology/Pain Medicine at UMMC, as medical director of the Louisville site for Capitol Pain Institute (2018-2020), and as a physician partner at Vitality Pain (2020-2023). He is a Fellow of the American Society of Anesthesiologists (FASA) and holds active memberships in the Kentucky Society of Anesthesiologists, the Kentucky Society of Interventional Pain Physicians, the American Society of Regional Anesthesia and Pain Medicine, and the National Medical Association. He has served as Principal Investigator on multiple clinical studies, including research involving spinal cord stimulation technology, and has contributed to peer-reviewed journals and textbook chapters in pain management.
Services:
- Stem Cell Therapy: Regenerative cell-based injections targeting damaged musculoskeletal tissue, offered as part of the practice’s broader regenerative medicine program.
- Platelet-Rich Plasma (PRP) Injections: Autologous platelet concentrate prepared from the patient’s own blood and injected into the target area to promote tissue healing and reduce inflammation.
- Interventional Pain Management: Fluoroscopically and/or ultrasound-guided injections including epidurals, nerve blocks, and joint injections using established interventional techniques.
- Neuromodulation: Advanced spinal cord stimulation and related therapies for patients with chronic intractable pain.
- Functional Wellness: Weight management, hormone therapy, and lifestyle-based approaches integrated with pain management care.
Conditions Treated:
- Chronic back and neck pain
- Knee, shoulder, and hip joint pain
- Degenerative disc disease
- Osteoarthritis
- Nerve pain and neuropathy
- Complex regional pain syndrome (CRPS)
- Post-surgical pain
- Headache and facial pain conditions
Technology and Equipment: Dr. Beacham employs fluoroscopic and ultrasound imaging guidance for interventional procedures, consistent with the standard of care for image-guided injections in interventional pain medicine.
2. Kentuckiana Integrative Medicine
Address: 405 E Court Ave, Suite 102, Jeffersonville, IN 47130 (approximately 5 miles from downtown Louisville, KY, across the Clark Memorial Bridge)
Phone: (812) 913-4416
Website: https://regenmedky.com
About: Kentuckiana Integrative Medicine is a physician-led regenerative and integrative medicine clinic located in Jeffersonville, Indiana, directly across the Ohio River from Louisville and widely accessible to Jefferson County patients. The clinic was established to address the gap between conventional medicine and conditions for which standard treatments offer limited long-term benefit, with a particular emphasis on chronic pain, musculoskeletal degeneration, and complex chronic illness. According to the clinic’s published materials, it is one of the most established practices in the region delivering regenerative orthobiologics, with the clinic’s lead physician having offered these treatments since 2010. The practice operates within a functional and integrative medicine philosophy, meaning that regenerative procedures are typically offered alongside nutritional, metabolic, and lifestyle interventions rather than as isolated injections. Kentuckiana Integrative Medicine uses ultrasound and/or fluoroscopic X-ray guidance for all regenerative injection procedures to ensure accurate product placement, which the clinic identifies as a key differentiator affecting treatment outcomes. The clinic serves patients from Louisville, southern Indiana, and surrounding Kentucky counties who are seeking alternatives to surgery or who have not achieved lasting relief through conventional pain management approaches.
Physicians:
- Rafael F. Cruz, MD, ABEM, CIME — Board certified in Emergency Medicine (certified 1997, re-certified 2007) and certified as an Independent Medical Examiner (2014). Dr. Cruz earned his MD from Wright State University School of Medicine (graduated 1993) and completed an Emergency Medicine residency at Mercy St. Vincent Medical Center/Mercy Health Partners (1993-1996). He subsequently completed an Anesthesiology residency at the University of Louisville School of Medicine (2002-2004), with a focus on anesthesia and pain procedures. Following his anesthesia training, Dr. Cruz shifted his full clinical focus to integrative, functional, and regenerative medicine — a transition he has maintained for over 20 years. He is a founding member and fellow of the American Academy of Ozone Therapists, trained in IV Nutritional Therapy and IV Chelation through ACAM, and has received advanced training in bone marrow aspiration, regenerative orthobiologics, prolotherapy, and ultrasound/fluoroscopic-guided injection techniques.
Services:
- Messenger Signaling Cell Therapy: A class of regenerative cell therapy utilizing signaling proteins intended to stimulate the body’s natural tissue repair and anti-inflammatory responses. The clinic uses this terminology to describe treatments involving cellular and extracellular signaling agents rather than traditional autologous stem cells.
- Platelet-Rich Plasma (PRP) Injections: Growth factor-concentrated plasma prepared from the patient’s blood and delivered to damaged joints, tendons, or soft tissue to promote healing.
- Bone Marrow Aspirate (BMA): A minimally invasive procedure in which bone marrow concentrate is harvested from the patient (typically from the iliac crest) and injected into the target area. The clinic describes the procedure as typically completed in under 15 minutes.
- Amniotic and Placental Regenerative Orthobiologics: Tissue-derived products containing growth factors, cytokines, and extracellular matrix components used to support tissue repair in musculoskeletal applications.
- Regenerative Tissue Allograft: Donor-derived tissue products applied in regenerative injection protocols.
- Prolotherapy and Prolozone: Injection-based stimulation therapy using dextrose solutions or ozone/oxygen mixtures to stimulate ligament and tendon repair.
- Ketamine Infusion Therapy: IV ketamine for treatment-resistant depression, chronic pain, PTSD, and related conditions.
- IV Nutritional and Chelation Therapy: Intravenous delivery of vitamins, minerals, and chelating agents as part of integrative protocols.
Conditions Treated:
- Osteoarthritis of the knee, hip, and shoulder
- Tendonitis and tendinopathy
- Torn or lax ligaments
- Sports injuries
- Degenerative joint disease
- Chronic musculoskeletal pain
- Cardiovascular disease (integrative/functional protocols)
- Neurological and mental health conditions (via ketamine and integrative approaches)
- Chronic fatigue and complex systemic illness
Technology and Equipment: The clinic uses ultrasound and/or fluoroscopic X-ray guidance for all regenerative injection procedures to confirm accurate needle positioning and orthobiologic product placement.
Patient Experience: The clinic operates Monday through Friday, 9:00 AM to 5:00 PM. Patients from Louisville typically cross via the Clark Memorial or Lewis and Clark bridges, with the clinic located approximately 10-15 minutes from downtown Louisville under normal traffic conditions.
3. Integrative Health Specialists
Address: 201 Townepark Circle, Suite 100, Louisville, KY 40243
Phone: (502) 412-3232
Website: https://www.ihsmed.net
About: Integrative Health Specialists (IHS) is a Louisville-based multi-physician practice founded in 2006 — originally established as Integrative Hormone Specialists, the first Louisville practice dedicated solely to bioidentical hormone replacement therapy and functional medicine. Over nearly two decades, the practice has expanded to encompass a broader range of integrative and preventive services, building one of the most credentialed physician teams in Louisville’s integrative medicine space. The practice takes an individualized approach to care, emphasizing the identification of root causes through functional medicine evaluation rather than symptomatic management alone. IHS is staffed by multiple board-certified physicians, several of whom hold dual training in Emergency Medicine and Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine (A4M). The practice serves patients from adolescence through adulthood, with clinical focus areas including functional medicine, hormonal health, metabolic optimization, aesthetic medicine, and integrative nutrition. Patients interested in regenerative or PRP-related services should contact the practice directly to confirm current service availability, as offerings have evolved with the practice’s growth. The Townepark Circle location in eastern Jefferson County provides convenient access for patients in the St. Matthews, Middletown, Hurstbourne, and Jeffersontown communities.
Physicians:
- Lori Sweat, MD — Founder of the practice. Graduated Summa Cum Laude from the University of Louisville School of Medicine (1992). Completed an Internal Medicine residency at the University of Louisville (1995) and served as Chief Medical Resident (1995-1996). Board certified in Bioidentical Hormone Replacement Therapy and Functional Medicine. Dr. Sweat established the practice in 2006 with a specific focus on individualized hormonal and preventive care.
- Jessica Dennison, MD — Graduated from the University of Louisville School of Medicine (2005). Completed an Emergency Medicine residency at the University of Louisville, serving as Chief Resident (2007-2008). Completed a fellowship in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine (A4M, 2014). Board certified in Emergency Medicine and by the American College of Lifestyle Medicine. Dr. Dennison serves as a Clinical Professor of Emergency Medicine at the University of Louisville.
- Martin Huecker, MD — Board-certified Emergency Medicine physician, Professor of Emergency Medicine, and Research Director at the University of Louisville. Member of Phi Beta Kappa and Alpha Omega Alpha honor societies.
- Jillian Stearman, MD — Completed an Emergency Medicine residency in 2008, serving as Chief Resident. Board certified in Emergency Medicine and by the American Academy of Anti-Aging and Regenerative Medicine (A4M, 2014). Clinical interests include disease prevention, hormone replacement therapy, metabolic health optimization, and evidence-based lifestyle interventions.
Services:
- Functional Medicine: Comprehensive evaluation targeting root causes of chronic illness, metabolic dysfunction, autoimmune conditions, and hormone imbalance through advanced laboratory testing and individualized protocols.
- Anti-Aging and Regenerative Medicine Consultations: Physician-led assessments drawing on A4M-trained clinicians for patients exploring regenerative approaches to aging, inflammation, and musculoskeletal health.
- Bioidentical Hormone Replacement Therapy (BHRT): Individualized hormone optimization for both men and women, including evaluation and management of thyroid, adrenal, and sex hormone imbalances.
- IV Infusion Services: Intravenous nutrient therapies (listed as coming soon on current published materials; patients should confirm current availability).
- Aesthetic Services: Medical aesthetic procedures including neuromodulators, dermal fillers, and microneedling.
- Integrative Nutrition Coaching: Individualized dietary and lifestyle intervention through credentialed dietitian and PA-level providers.
- Mold Toxicity Testing and Treatment: Evaluation and management of mycotoxin-related illness within a functional medicine framework.
Conditions Treated:
- Hormonal imbalance and deficiency (men and women)
- Thyroid disorders
- Metabolic syndrome and insulin resistance
- Chronic fatigue and fibromyalgia
- Autoimmune and inflammatory conditions
- Aging-related functional decline
- Mood disorders and cognitive concerns addressed through functional medicine evaluation
- Mold and environmental toxin illness
What to Know Before Choosing a Stem Cell Clinic in Louisville
Before scheduling a consultation at any regenerative medicine clinic in Louisville or the surrounding area, patients benefit from preparing a targeted set of questions. The most important opening question is straightforward: is the treating physician board certified in a specialty that involves musculoskeletal medicine, pain management, or regenerative procedures — and can you verify that certification through the American Board of Medical Specialties at abms.org? Kentucky physician licensure can be independently verified through the Kentucky Board of Medical Licensure at kbml.ky.gov. For clinics across the state line in Indiana, licensure verification is available through the Indiana Professional Licensing Agency. Board certification and licensure are non-negotiable baseline requirements, not optional considerations.
Ask specifically about imaging guidance. Regenerative injections placed without fluoroscopic or ultrasound guidance rely on surface anatomy alone to locate target structures, which significantly reduces placement accuracy compared to image-guided techniques. Experienced interventional physicians in Louisville — including those at the clinics listed above — routinely use fluoroscopic or ultrasound guidance for joint and soft tissue injections. Patients should ask whether the clinic uses guidance, what type, and whether the physician performing the injection is credentialed in image-guided procedures. Guidance capability is a meaningful quality indicator that separates specialist-level care from less rigorous approaches.
Understand the regulatory status of any product being injected into your body. The FDA regulates biological products used in cellular therapies, and the regulatory framework distinguishes between autologous procedures (using your own cells, such as PRP or bone marrow aspirate) and allogeneic products derived from donor tissue. Some amniotic, placental, and cord blood products fall under FDA enforcement discretion policies that are subject to change; others require specific regulatory clearance. Ask the clinic which specific products they use, whether those products are FDA-cleared or fall under a specific regulatory pathway, and whether they can provide product labeling or documentation. Reputable clinics welcome this question and provide clear answers.
Evaluate the clinic’s approach to pre-treatment assessment. A stem cell or regenerative medicine clinic operating at a responsible standard will require imaging (typically MRI or X-ray) and a thorough clinical evaluation before recommending any procedure. Clinics that offer procedures based on a phone consultation alone, or that recommend the same treatment to all patients regardless of diagnosis, are operating below the standard you should expect. Louisville has the imaging infrastructure and specialist capacity to support proper pre-procedural workup — major hospitals including UofL Health, Baptist Health, Norton Healthcare, and multiple outpatient imaging centers can provide MRI, musculoskeletal ultrasound, and laboratory studies. The right clinic will integrate those findings into a treatment decision rather than treat them as a formality.
Disclaimer: This directory is for informational purposes only. Inclusion does not constitute endorsement. Clinic information reflects data available as of February 2026 and may have changed; verify all details — including addresses, phone numbers, physician credentials, and available services — directly with each clinic before scheduling any appointment or treatment. Consult a licensed physician before pursuing any medical therapy.