Overview
Orlando is home to one of Florida’s most developed healthcare ecosystems, anchored by major academic medical centers, nationally accredited cancer institutes, and a growing number of specialized regenerative medicine practices. The metropolitan area supports more than 3.5 million residents across Orange, Seminole, Osceola, and Lake counties, and its concentration of tertiary care facilities means that patients seeking advanced cellular therapies do not have to travel to Miami, Tampa, or out of state. Two health systems — AdventHealth and Orlando Health — maintain hospital-grade cellular therapy programs that carry national accreditation, while independent physician-owned practices fill the outpatient gap with musculoskeletal and pain-focused regenerative treatments.
Patients pursue stem cell therapy in Orlando for a wide range of reasons. The most clinically established applications involve hematologic malignancies: leukemia, lymphoma, multiple myeloma, and myelodysplastic syndromes, where autologous or allogeneic transplants represent a curative or remission-extending standard of care. A second, faster-growing patient population seeks outpatient regenerative procedures for orthopedic and musculoskeletal conditions — chronic joint pain, tendon injuries, osteoarthritis, and spinal disc disorders — where platelet-rich plasma (PRP) and biologic injections are offered as non-surgical alternatives. Understanding which category of therapy you need is the single most important step before contacting any clinic.
Clinics in Orlando generally fall into three categories. Hospital-based cellular therapy programs operate under oncology departments, require a formal diagnosis and referral, and are held to FACT (Foundation for the Accreditation of Cellular Therapy) accreditation standards. These programs perform bone marrow and peripheral blood stem cell transplants with multidisciplinary teams. Independent outpatient regenerative medicine clinics operate under physician oversight — most commonly physiatrists, pain medicine specialists, or orthopedic physicians — and offer procedures such as PRP injections and amniotic- or umbilical cord-derived biologic products. A third category includes concierge or integrative medicine practices that combine regenerative techniques with broader wellness protocols.
Evaluating any stem cell clinic in Orlando requires attention to four criteria: (1) the treating physician’s board certifications, training institution, and licensure status with the Florida Department of Health; (2) whether the facility holds relevant accreditation such as FACT for transplant programs or AAAHC for outpatient surgical suites; (3) transparency about what the product actually contains, how it is processed, and whether it complies with FDA guidelines for human cells, tissues, and cellular and tissue-based products (HCT/Ps) under 21 CFR Part 1271; and (4) realistic outcome data or peer-reviewed clinical evidence supporting the specific indication being treated. Any clinic that guarantees results, refuses to disclose physician credentials, or discourages consultation with your primary care provider warrants extreme caution.
Top Stem Cell Therapy Clinics in Orlando
1. AdventHealth Medical Group — Stem Cell Transplant and Cellular Therapy at Orlando
Address: 2415 North Orange Avenue, Suite 601, Orlando, FL 32804
Phone: (407) 303-2070
Website: https://www.adventhealth.com/practice/adventhealth-medical-group/adventhealth-medical-group-stem-cell-transplant-and-cellular-therapy-orlando
About: AdventHealth Medical Group’s Stem Cell Transplant and Cellular Therapy program in Orlando is Central Florida’s first and only comprehensive blood and marrow transplant center, with its autologous program dating to 1996 and its allogeneic program to 1997. The program holds FACT accreditation for both autologous and allogeneic transplants, a standard recognized globally as the benchmark for cellular therapy quality. Physicians perform more than 140 transplants per year, making it one of the highest-volume programs in the southeastern United States. The facility houses a state-of-the-art cellular therapy suite supported in part by a $1 million contribution from Kids Beating Cancer, enabling both adult and pediatric CAR-T cell therapy alongside conventional transplantation. The program has also been designated a Center of Excellence by the MDS Foundation for its work in myelodysplastic syndromes, and its physicians are active members of the Center for International Blood and Marrow Transplant Research (CIBMTR).
Physicians:
- Dr. Rushang Patel, MD — Hematology and Oncology / Cell Therapy. Dr. Patel earned his medical degree from Baroda Medical College and completed a fellowship in hematology and oncology at Fox Chase Cancer Center (an NCCN-designated institution) as well as a fellowship in bone marrow transplantation at Temple University. He holds board certification in Internal Medicine, Hematology, and Medical Oncology from the American Board of Internal Medicine. Dr. Patel brings more than 20 years of clinical experience and has conducted research in collaboration with UNICEF, Alembic Pharmaceuticals, and Sanofi-Aventis, focusing on mechanisms of cancer formation and novel drug targets.
- Dr. Shahram Mori, MD, PhD — Also affiliated with the program at 2415 N. Orange Ave., Suite 601.
- Dr. Arlene Gayle, MD and Dr. Brian Parkin, MD — Both listed with AdventHealth Medical Group Blood and Marrow Transplant at Orlando.
Services:
- Autologous Stem Cell Transplant: Stem cells are harvested from the patient’s own blood or marrow prior to high-dose chemotherapy, cryopreserved, and reinfused following treatment to reconstitute the patient’s hematopoietic system.
- Allogeneic Stem Cell Transplant: Uses stem cells from a genetically matched family member or unrelated donor identified through national registries, suitable for conditions requiring replacement of the patient’s own marrow.
- Peripheral Blood Stem Cell Transplant: A non-surgical approach to harvesting stem cells from circulating blood using apheresis, then transplanting them autologously or allogeneically.
- CAR-T Cell Therapy: Chimeric antigen receptor T-cell therapy reengineers the patient’s own immune cells to recognize and attack cancer cells; available for select lymphoma and leukemia indications.
- Pediatric Cellular Therapy: The AdventHealth for Children Pediatric Cellular Therapy Program is the only program of its kind in Central Florida, offering individualized treatment plans for children with blood cancers and marrow failure syndromes.
Conditions Treated:
- Acute and chronic leukemias (AML, CML, ALL, CLL)
- Lymphoma (Hodgkin and non-Hodgkin)
- Multiple myeloma
- Myelodysplastic syndromes (MDS)
- Myelofibrosis
- Bone marrow failure syndromes
- Sickle cell anemia
- Aplastic anemia
- Select solid tumors (autologous context)
Accreditation and Recognition: FACT accredited (autologous and allogeneic); MDS Foundation Center of Excellence; CIBMTR member institution.
2. Orlando Health Cancer Institute — Bone Marrow Transplant and Cellular Therapy Program
Address: 1400 S. Orange Ave., Orlando, FL 32806
Phone: (407) 648-3800
Website: https://www.orlandohealth.com/services-and-specialties/orlando-health-cancer-institute/specialty-centers/bone-marrow-transplant-and-cellular-therapy-program
About: The Orlando Health Cancer Institute Bone Marrow Transplant and Cellular Therapy Program is a FACT-accredited center providing both autologous and allogeneic transplant services to adult and pediatric patients at 1400 S. Orange Avenue, the main campus of Orlando Health-Orlando Regional Medical Center. Since launching transplant services in 2020, the program has completed more than 217 bone marrow transplants as of its most recent public reporting, with outcomes ranking in the top 10% nationally according to FACT evaluations. The program is listed in the NMDP (National Marrow Donor Program) Global Transplant Network directory, confirming its participation in national donor matching infrastructure. A key clinical differentiator is the program’s recognition by the Center for International Blood and Marrow Transplant Research among the nation’s top 12 performing centers for CAR-T cell therapy. Patients benefit from receiving transplant and all follow-up care in a single location without the need to travel to distant transplant centers.
Physicians:
- Dr. Yasser A. Khaled, MD — Medical Director, Bone Marrow Transplant and Cellular Therapy. Dr. Khaled received his medical degree from Cairo University School of Medicine and completed fellowships in medical oncology at Virginia Commonwealth University, hematology at New York Medical College, and blood and bone marrow transplantation at UT/MD Anderson Cancer Center, one of the world’s leading cancer institutions. He is board certified in Hematology by the American Board of Internal Medicine. Prior to joining Orlando Health, Dr. Khaled served as Medical Director of the Blood and Marrow Transplant Center at Methodist Le Bonheur Healthcare in Memphis, where in under four years he led the program to a top 10% national ranking in survival outcomes. He brought the first CAR-T cell therapy for lymphoma and acute leukemia to Memphis and the Mid-South, earning the Memphis Health Care Hero award in 2019. He has served as principal investigator on multiple NIH- and industry-funded protocols and has published extensively in the field.
Services:
- Autologous Bone Marrow Transplant: Patient’s own stem cells are collected, frozen, and reinfused following intensive chemotherapy to restore marrow function after treatment.
- Allogeneic Bone Marrow Transplant: Donor stem cells from a matched family member or unrelated registry donor are used to replace diseased marrow, often with a graft-versus-tumor effect providing additional therapeutic benefit.
- CAR-T Cell Therapy: Available for eligible patients with relapsed or refractory lymphoma and acute leukemia; the program is among the top 12 nationally recognized CAR-T centers per CIBMTR data.
- Multidisciplinary Supportive Care: The team includes oncologists, pathologists, radiologists, nurses, physical and occupational therapists, and counselors integrated into a single-site care model.
- Online Patient Portal: Patients can securely access health records, test results, and care communications through Orlando Health’s online portal.
Conditions Treated:
- Acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL)
- Chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML)
- Hodgkin and non-Hodgkin lymphoma
- Multiple myeloma
- Myelodysplastic syndromes
- Bone marrow failure and aplastic anemia
- Pediatric blood cancers and marrow disorders
Accreditation: FACT accredited; listed in the NMDP Global Transplant Network; outcomes ranked top 10% nationally.
Insurance: Accepts Medicare, Cigna, United Healthcare, and other major insurance plans; new patients accepted.
3. Florida Wellness and Regenerative Medicine LLC
Address: 7345 W. Sand Lake Rd., Suite 301, Orlando, FL 32819
Phone: (321) 204-8237
Fax: (407) 990-7962
Website: https://flwellnessmd.com
About: Florida Wellness and Regenerative Medicine LLC is an independent outpatient practice on Orlando’s southwest side, focused on non-surgical interventional pain management and regenerative medicine for musculoskeletal and neurological conditions. The practice is physician-owned and operated by Dr. Diana Hussain, MD, one of the region’s most credentialed physiatrists, and serves a bilingual patient population in both English and Spanish. The clinic’s regenerative offerings center on image-guided platelet-rich plasma (PRP) injections and exosome-based therapies, administered under ultrasound or fluoroscopic visualization to maximize precision and therapeutic effect. The practice takes an individualized approach, combining regenerative procedures with comprehensive rehabilitation planning rather than offering procedures as standalone interventions. Dr. Hussain has been recognized in Orlando Magazine’s “Finest Physicians” list from 2018 through 2025, reflecting consistent peer and patient recognition over a sustained period in the Central Florida medical community.
Physicians:
- Dr. Diana A. Hussain, MD — Physical Medicine and Rehabilitation / Pain Medicine. Dr. Hussain completed her internship in General Surgery and her residency in Physical Medicine and Rehabilitation at the Mayo Clinic in Rochester, MN, consistently ranked among the top medical institutions in the world. She holds double board certification from the American Board of Physical Medicine and Rehabilitation and the American Board of Pain Medicine. She serves as an Assistant Professor of Physical Medicine and Rehabilitation at the University of Central Florida (UCF) College of Medicine and holds hospital privileges at Orlando Health, AdventHealth Orlando, and Celebration Hospital. Dr. Hussain currently serves as President of the Florida Society of Physical Medicine and Rehabilitation, the state professional society for her specialty. She is fluent in Spanish.
Services:
- Platelet-Rich Plasma (PRP) Injections: PRP is derived from the patient’s own blood; plasma concentrated with growth factors is extracted and injected into the site of injury or degeneration under image guidance to stimulate tissue repair and reduce inflammation. Indicated for joint degeneration, tendon injuries, and chronic musculoskeletal pain.
- Exosome Therapy: Exosomes are extracellular vesicles that carry regenerative signaling molecules; when administered locally, they support cellular communication and tissue healing responses in damaged structures.
- Electrodiagnostic Testing (EMG/NCS): Nerve conduction studies and electromyography to evaluate and diagnose nerve and muscle conditions, providing objective data to guide regenerative treatment planning.
- Interventional Spinal Injections: Epidural steroid injections, facet joint injections, and radiofrequency ablation procedures for cervical, thoracic, and lumbar spine pain.
- Joint Injections: Image-guided injections for shoulder, hip, knee, ankle, and other peripheral joints, including both conventional corticosteroid and regenerative biologic options.
- Kyphoplasty and Sacroiliac Stabilization: Minimally invasive procedures for vertebral compression fractures and sacroiliac joint dysfunction.
- Botox and Neuromodulator Injections: Over 15 years of experience administering botulinum toxin for therapeutic uses including chronic migraine prophylaxis, spasticity, and cervical dystonia.
Conditions Treated:
- Knee osteoarthritis and joint degeneration
- Shoulder pain and rotator cuff tendinopathy
- Tennis elbow (lateral epicondylitis) and other tendon injuries
- Hip pain and labral pathology
- Lumbar and cervical disc disease and radiculopathy
- Sacroiliac joint dysfunction
- Chronic migraine
- Spasticity and neuromuscular conditions
- Vertebral compression fractures
Patient Experience: Dr. Hussain has been featured in Orlando Magazine’s “Finest Physicians” annually from 2018 through 2025. Patient reviews describe efficient yet careful procedural technique and meaningful outcomes for chronic pain conditions. The clinic serves both English- and Spanish-speaking patients.
What to Know Before Choosing a Stem Cell Clinic in Orlando
Before committing to any stem cell or regenerative medicine clinic in Orlando, ask direct questions about the treating physician’s credentials. Board certification is the baseline: for hematologic stem cell transplants, look for certification from the American Board of Internal Medicine in hematology or medical oncology; for outpatient musculoskeletal regenerative procedures, look for certification in orthopedics, physical medicine and rehabilitation, or pain medicine. Florida physician license status can be verified instantly through the Florida Department of Health’s MQA Online Services portal at mqa.doh.state.fl.us. Any licensed MD or DO practicing in Florida must appear in that database. A clinic that cannot provide the treating physician’s full name and credentials before you arrive is not operating transparently.
Ask specifically what biological product will be used and how it is regulated. The FDA classifies most stem cell and biologic products used in outpatient regenerative medicine under 21 CFR Part 1271, which governs human cells, tissues, and cellular and tissue-based products. Products that meet the criteria for “minimal manipulation” and “homologous use” are exempt from the premarket approval pathway but must still comply with donor eligibility, processing, and labeling requirements. Products that do not meet these criteria — including many culture-expanded cell therapies — require an Investigational New Drug application or biologics license. Asking whether the product being used is FDA-cleared, registered, or investigational is a reasonable and important question. Reputable clinics will answer it directly.
Diagnostic rigor matters before any regenerative procedure. For musculoskeletal conditions, appropriate workup should include imaging such as X-ray or MRI to characterize the extent and nature of the pathology. Injecting a biologic product into a joint or tendon without first confirming the structural diagnosis is clinically poor practice. For hematologic conditions requiring transplant, diagnosis will typically involve bone marrow biopsy, cytogenetics, flow cytometry, and molecular testing. Orlando’s hospital-based programs — including those at AdventHealth and Orlando Health — integrate these diagnostics into their standard evaluation before any transplant is scheduled. Outpatient regenerative clinics should similarly require relevant imaging and laboratory work before scheduling procedures.
Finally, consider the referral and follow-up structure. Hospital-based transplant programs typically require referral from a treating hematologist or oncologist. Outpatient regenerative clinics often accept self-referrals, but the highest-quality practices will still insist on a thorough initial consultation before scheduling any procedure. Ask how complications are managed, what follow-up looks like, and whether the physician performing the procedure is the same one who conducted your consultation. In Orlando’s outpatient regenerative medicine market specifically, the combination of a board-certified physician, image-guided technique, and transparent product disclosure — as practiced at clinics like Florida Wellness and Regenerative Medicine — represents the standard of care that patients should expect and demand.
Disclaimer: This directory is for informational purposes only. Inclusion does not constitute endorsement. Credentials, addresses, phone numbers, and services were verified against publicly available sources as of February 2026 but may change. Verify all information directly with each clinic. Consult a licensed physician before pursuing any treatment.