Overview
San Jose sits at the center of Silicon Valley, a region that has consistently attracted elite medical talent and pioneered advanced healthcare delivery models. The South Bay’s healthcare infrastructure reflects the same emphasis on precision, innovation, and outcomes-driven thinking that defines its technology sector. Patients in San Jose and the surrounding communities of Campbell, Saratoga, Los Gatos, Cupertino, Sunnyvale, and Santa Clara have access to a concentrated cluster of orthopedic and sports medicine specialists who offer regenerative medicine as a complement or alternative to conventional surgical care.
Regenerative medicine, including stem cell therapy, draws patients who are seeking non-surgical options for musculoskeletal conditions that have not responded adequately to physical therapy, corticosteroid injections, or anti-inflammatory medications. The conditions most commonly driving San Jose patients toward these clinics include knee and hip osteoarthritis, rotator cuff injuries, tendinopathies, ligament damage, and cartilage degeneration. For many patients, the appeal lies in procedures that use the body’s own biological materials — or carefully selected allograft biologics — to promote tissue repair and reduce inflammation without the recovery time and risk profile associated with surgery.
The clinics operating in this space generally fall into two categories. The first is the physician-led orthopedic or sports medicine practice, where a board-certified MD or DO with fellowship training in orthopedic surgery or sports medicine integrates regenerative therapies alongside a full scope of musculoskeletal care. These clinics typically perform in-office procedures under ultrasound or fluoroscopic guidance and maintain direct physician involvement from consultation through follow-up. The second category includes multi-location networks or medical spa environments where regenerative treatments may be offered more broadly, often with less physician-specific involvement in each case. For conditions involving joint damage, cartilage injury, or post-surgical recovery, the physician-led model generally provides stronger clinical oversight and more precise procedural targeting.
Evaluating a stem cell clinic in San Jose requires attention to several factors: whether a licensed physician will personally administer the treatment or supervise it directly, what imaging is used to guide injections, whether the clinic uses autologous (patient-derived) or allogeneic (donor-derived) biologics and can explain the distinction clearly, and whether the practice holds any institutional affiliations or has published outcomes data. The clinics listed below meet the baseline criteria of physician leadership, verifiable physical addresses, and active https-secured websites.
Top Stem Cell Therapy Clinics in San Jose
1. Resilience Orthopedics
Address: 2430 Samaritan Dr, San Jose, CA 95124
Phone: (408) 559-3888
Website: https://www.resilienceorthopedics.com
About: Resilience Orthopedics is a private orthopedic practice founded by Dr. Pamela Mehta, MD, built around a concierge-level model of care that emphasizes direct, one-on-one access to the physician at every stage of treatment. The practice treats the full spectrum of orthopedic conditions — knee, shoulder, hip, hand, wrist, and foot and ankle — with a stated commitment to exhausting non-surgical options before recommending operative intervention. Dr. Mehta founded the practice after several years working within a large managed care organization, where she found the institutional model limited the kind of individualized attention she wanted to provide each patient. The clinic maintains a 96 percent patient satisfaction rating with over 200 five-star reviews across multiple platforms, reflecting consistent patient experience outcomes. Resilience Orthopedics serves patients throughout the South Bay, including San Jose, Los Gatos, Campbell, Saratoga, Cupertino, Sunnyvale, Santa Clara, and Mountain View, and operates a concierge assistance process to help patients navigate insurance authorizations where applicable.
Physicians:
- Dr. Pamela Mehta, MD — Board-certified orthopedic surgeon; graduated cum laude from the University of Southern California with a B.A. in Biology and Religion; completed medical school at Keck School of Medicine of USC (Class of 2006); completed orthopaedic surgery residency at New York-Presbyterian Hospital, Columbia University (2006-2011), training under Dr. Louis Bigliani, pioneer of the modern shoulder replacement; over 20 years of clinical experience in orthopedic surgery and regenerative medicine; Chief Medical Officer of The Good Feet Store; co-founder of Pinnacle, a national conference for women in healthcare; featured in publications by Columbia University Orthopedics
Services:
- Platelet-Rich Plasma (PRP) Therapy: Blood is drawn from the patient, centrifuged to concentrate the platelet fraction, and injected into the injured tissue under guidance to stimulate the body’s repair cascade and reduce inflammation at the site of injury.
- Stem Cell Therapy (Lipogems, Clarix FLO, Amniofix): The clinic offers three distinct stem cell formulations depending on the clinical picture — Lipogems uses autologous fat-derived cells harvested from the patient; Clarix FLO delivers allogeneic umbilical stem cells containing a broad spectrum of growth factors; Amniofix is derived from amniotic membrane tissue and is used to reduce inflammation and support soft tissue healing.
- Bone Marrow Aspirate Concentrate (BMAC): Stem cells are harvested from the patient’s own iliac crest via needle aspiration, concentrated in a laboratory centrifuge, and injected into the affected joint or tissue to maximize the concentration of mesenchymal stem cells at the repair site.
Conditions Treated:
- Knee osteoarthritis and cartilage damage
- ACL tears and meniscus injuries
- Rotator cuff tears
- Shoulder arthritis and frozen shoulder
- Hip arthritis and labral injuries
- Tennis elbow and biceps tendinopathy
- Plantar fasciitis
- Ligament and muscle strains
- Post-surgical recovery support
Technology and Equipment:
The clinic performs imaging-guided regenerative procedures and conducts diagnostic evaluation using X-ray and MRI prior to treatment planning. Lipogems, Clarix FLO, and Amniofix biologics are sourced from established medical-grade suppliers and are selected based on the nature and severity of each patient’s condition.
Patient Experience:
The initial consultation involves a full physical examination, review of prior imaging, and a discussion of the patient’s lifestyle goals and treatment history rather than a protocol-first approach. Procedures are performed in-clinic on an outpatient basis. Dr. Mehta remains involved in follow-up care and adjusts treatment plans based on the patient’s recovery trajectory. The concierge model allows for direct physician access and individualized scheduling.
2. Skyline Sports Medicine
Address: 2430 Samaritan Dr, San Jose, CA 95124
Phone: (408) 559-3889
Website: https://svetlanadanimd.com
About: Skyline Sports Medicine is a board-certified sports medicine practice in San Jose led by Dr. Svetlana Dani, MD, focused on non-surgical, non-invasive management of musculoskeletal conditions across all patient populations — from competitive athletes to recreational exercisers to adults managing chronic joint degeneration. Dr. Dani developed an interest in sports medicine as a child gymnast and pursued it through pediatric residency training and a dedicated sports medicine fellowship, giving her a distinctive clinical perspective that spans pediatric and adult populations. Her work with NCAA Division I athletes at the University of Maryland and with the Baltimore Ravens NFL team prior to establishing her San Jose practice provided high-level exposure to acute sports injuries, performance medicine, and regenerative treatment protocols under competitive conditions. The practice operates with an emphasis on non-invasive techniques, meaning regenerative injections are delivered without surgical intervention and often with same-day recovery. The clinic is co-located at 2430 Samaritan Drive in San Jose alongside Resilience Orthopedics, offering patients in the building access to both orthopedic surgery and sports medicine expertise.
Physicians:
- Dr. Svetlana Dani, MD — Board-certified sports medicine specialist; completed pediatrics residency at New York University Medical Center; completed sports medicine fellowship at the University of Maryland, where she served as team physician for the NCAA Division I Maryland Terrapins athletics program and worked with the Baltimore Ravens of the NFL; specializes in injury prevention, regenerative medicine, ultrasound-guided injections, and rehabilitation before and after surgery
Services:
- Platelet-Rich Plasma (PRP) Injections: Patient blood is drawn and processed via centrifugation to isolate and concentrate platelets and growth factors; the full procedure takes approximately 30 minutes; PRP is injected into the affected joint or soft tissue to reduce inflammation and accelerate the healing response.
- Stem Cell Therapy with Clarix FLO: Clarix FLO is an injectable allogeneic biologic derived from umbilical tissue containing a concentrated array of growth factors that modulate the inflammatory response and stimulate tissue regeneration; it is used as an alternative or complement to autologous cell harvesting and can be combined with PRP or the Tenex procedure for optimized outcomes.
- Ultrasound-Guided Injections: All regenerative procedures are performed under ultrasound guidance to ensure accurate anatomical targeting and maximize the precision of biologic delivery to the injured site.
- Tenex Procedure: A minimally invasive ultrasound-guided procedure that uses high-frequency energy to remove damaged tendon tissue, typically used for chronic tendinopathies such as tennis elbow, Achilles tendinitis, and plantar fasciitis.
- Barbotage Procedure: An ultrasound-guided technique for calcium deposits in tendons (calcific tendinitis), in which the calcium is needled, broken up, and aspirated from the tendon sheath.
- Nerve Hydrodissection: Injection of fluid around a compressed or entrapped peripheral nerve to release adhesions and reduce pain.
- Concussion Clinic: Evaluation and management of concussion and post-concussion syndrome using evidence-based protocols.
- Sports Medicine and Nutrition Counseling: Integrated management of athletic health including return-to-sport planning and nutritional support for recovery.
Conditions Treated:
- Knee osteoarthritis and cartilage injuries
- Shoulder arthritis and rotator cuff injuries
- Hip osteoarthritis and labral conditions
- Plantar fasciitis and Achilles tendinitis
- Calcific tendinitis
- Ligament injuries
- Muscle tears
- Chronic tendinopathies
- Sports injuries across all activity levels
- Concussion and post-concussion syndrome
Technology and Equipment:
Ultrasound guidance is used for all injection-based procedures, including PRP, Clarix FLO stem cell injections, nerve hydrodissection, and the Barbotage procedure, ensuring real-time visualization and precise delivery. The practice uses centrifugation-based PRP processing.
Patient Experience:
Dr. Dani conducts individualized consultations to assess the extent of joint or soft tissue damage and determine which regenerative approach — PRP, Clarix FLO, or a combination protocol — best suits the patient’s condition and goals. Procedures are performed in-clinic without surgical intervention. Clarix FLO can be combined with additional treatments such as PRP and the Tenex procedure in a single visit when clinically appropriate. Office hours are Monday through Friday, 8:00 AM to 6:00 PM.
3. Smart Orthopaedic Surgery
Address: 200 Jose Figueres Ave, Suite 230, San Jose, CA 95116
Phone: (408) 364-1673
Website: https://www.smartorthopaedicsurgery.com
About: Smart Orthopaedic Surgery is a board-certified, fellowship-trained orthopedic surgery practice founded by Dr. Jothi Murali-Larson, MD, serving patients in the San Jose, Fremont, Milpitas, and Campbell areas. Dr. Murali-Larson has practiced as a sports medicine and trauma surgeon in the South Bay since 2016 and brings fellowship-level training in both orthopedic surgery and sports medicine to each case. The practice offers a full scope of orthopedic surgical and non-surgical services, with a dedicated focus on regenerative medicine as a pathway for patients who want to avoid or delay operative intervention. The San Jose location at 200 Jose Figueres Ave, Suite 230 provides patients in the East San Jose corridor direct access to fellowship-level orthopedic care within the community. The practice holds a 4.9-star rating with verified patient reviews and maintains a secondary office in Campbell at 429 Llewellyn Ave. Dr. Murali-Larson’s training at two leading academic medical institutions and her experience with both trauma and elective orthopedic cases gives her a broad clinical foundation for evaluating when regenerative medicine is appropriate versus when surgical intervention offers better long-term outcomes.
Physicians:
- Dr. Jothi Murali-Larson, MD — Board-certified orthopedic surgeon; completed medical school at Emory University School of Medicine; completed orthopedic surgery fellowship at Rhode Island Hospital, Brown Alpert Medical School; completed sports medicine fellowship at the University of California, Davis Health System; certified by the American Board of Orthopaedic Surgery; specializes in shoulder surgery, elbow surgery, knee surgery, foot and ankle surgery, sports injuries, shoulder replacement, fractures, and regenerative medicine; practicing in the San Jose area since 2016
Services:
- Stem Cell Therapy (BMAC): Autologous mesenchymal stem cells are harvested from the patient’s iliac crest via bone marrow aspiration, concentrated in a laboratory centrifuge over 10 to 15 minutes, and injected under fluoroscopic guidance into the degenerative or injured site; the full procedure typically requires less than one hour and is performed on an outpatient basis.
- Bone Marrow Aspirate Concentrate (BMAC): A concentrated preparation of bone marrow-derived stem cells and growth factors that is rich in mesenchymal stem cells with the capacity to differentiate into tendon, ligament, cartilage, and bone tissue; used to reduce inflammation and stimulate structural repair in orthopedic conditions.
- Platelet-Rich Plasma (PRP) Injections: Patient blood is processed to produce a concentration of platelets and growth factors 5 to 10 times greater than baseline; injected into damaged tissue during an outpatient procedure or following repair surgery to accelerate healing and reduce inflammation.
- Prolotherapy: Injection of a natural irritant into damaged soft tissue or joint structures to provoke a controlled inflammatory response that triggers the body’s intrinsic healing mechanism; primarily used for ligament and joint instability, including chronic back injuries.
- Autologous Cell Therapy: Combined use of platelet isolation from blood and stem cell isolation from bone marrow to deliver a concentrated biologic preparation to the target tissue.
- Cartilage Restoration: Restoration of articular cartilage using transplantation from another region of the patient’s body or from a donor source, performed in cases where cartilage loss is focal and surgical intervention is the appropriate pathway.
- Orthopedic Surgery (shoulder, elbow, knee, foot and ankle): Arthroscopic and open surgical procedures for acute and degenerative orthopedic conditions.
Conditions Treated:
- Shoulder osteoarthritis, rotator cuff tears, and shoulder replacement
- Elbow injuries and tennis elbow
- Knee osteoarthritis, ACL tears, meniscus injuries, and cartilage degeneration
- Foot and ankle conditions
- Ligament injuries and instability
- Tendon injuries and tendinopathies
- Muscle and soft tissue injuries
- Bone fractures and trauma
- Degenerative conditions of the hip and spine
- Sports injuries at all levels
Technology and Equipment:
Stem cell and BMAC procedures are performed under fluoroscopic (X-ray) guidance to confirm accurate placement into the target joint or tissue. The practice is equipped for in-office bone marrow aspiration and centrifugation. Orthopedic surgical procedures are performed at affiliated surgical facilities.
Patient Experience:
The clinic operates Monday through Friday, 8:00 AM to 5:00 PM. New patients can request appointments online or by phone. The practice provides patient education resources, downloadable forms, and a billing department reachable at (408) 833-6163. The San Jose office at 200 Jose Figueres Ave provides access to East San Jose, Milpitas, and surrounding communities, while the Campbell office at 429 Llewellyn Ave serves patients in the southwest portion of Santa Clara County.
What to Know Before Choosing a Stem Cell Clinic in San Jose
Before committing to any regenerative medicine treatment in San Jose, the most important question to ask is who will personally administer the injection and what qualifies them to do so. In physician-led practices, the treating MD or DO performs the procedure and takes clinical responsibility for the outcome. In some multi-location or network-model clinics, injections may be administered by mid-level providers under general physician supervision rather than direct involvement. For joints or tissues where precise anatomical targeting is critical — the knee joint space, a rotator cuff tendon insertion, or the hip labrum — direct physician administration under real-time imaging guidance produces the most reliable delivery. Confirm whether ultrasound or fluoroscopic guidance is used for every injection, not just as an optional add-on.
Ask about imaging before any treatment begins. A responsible regenerative medicine clinic will want to review current MRI or X-ray findings before proceeding, because the choice of biologic and the injection approach should be calibrated to the nature and severity of the tissue damage. A clinic that is willing to proceed with stem cell injections based on a patient’s self-reported symptoms alone, without reviewing diagnostic imaging, is a clinical red flag. In San Jose, the physician-led practices typically integrate imaging review into the initial consultation, and some will order new imaging if prior studies are outdated or inadequate for treatment planning.
Understand the distinction between autologous and allogeneic biologics before signing a consent form. Autologous treatments — such as PRP drawn from your own blood or BMAC harvested from your own bone marrow — use your body’s own cellular material, which eliminates the risk of immune rejection but requires an additional harvesting procedure. Allogeneic treatments — such as Clarix FLO derived from umbilical tissue — come from donor sources and undergo processing and screening before use; they do not require harvesting from the patient but carry their own considerations regarding regulatory status and evidence base. Ask your physician which formulation they recommend for your specific condition and what the clinical rationale is.
Board certification and fellowship training are meaningful proxies for clinical depth in this space. In California, any licensed MD or DO can legally offer regenerative medicine treatments, but fellowship training in orthopedic surgery or sports medicine indicates that the physician has completed structured post-residency training specifically focused on musculoskeletal conditions and interventional techniques. The American Board of Orthopaedic Surgery (ABOS) and the American Board of Family Medicine’s Certificate of Added Qualifications in Sports Medicine are the relevant credentials to verify. All three clinics listed in this guide are led by physicians who hold board certification and have completed fellowship training at accredited institutions. When evaluating any clinic not included here, ask for the physician’s board certification status, fellowship institution, and how many regenerative procedures they perform annually.
Disclaimer: This directory is for informational purposes only. Inclusion does not constitute endorsement. Verify credentials and consult a licensed physician before pursuing any treatment.